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Table 1 Summary of lubricant sequences used over 4 – 5 consecutive days of testing

From: Cartilage boundary lubrication synergism is mediated by hyaluronan concentration and PRG4 concentration and structure

Test

Lubricant [PRG4] (μg/mL), [HA] (mg/ml)

1

2

3

4

5

1A: PRG4 low dose, HA (N = 4)

PBS

[PRG4] = 4.5

[PRG4] = 45

[PRG4] = 150

SF

[HA] = 3.33

[HA] = 3.33

[HA] = 3.33

1B: PRG4 high dose, HA (N = 6)

PBS

[PRG4] = 150

[PRG4] = 450

[PRG4] = 1500

SF

[HA] = 3.33

[HA] = 3.33

[HA] = 3.33

2A: PRG4 high, HA dose (N = 8)

PBS

[PRG4] = 450

[PRG4] = 450

[PRG4] = 450

SF

[HA] = 0.3

[HA] = 1.0

[HA] = 3.33

2B: PRG4 mid, HA dose (N = 4)

PBS

[PRG4] = 150

[PRG4] = 150

[PRG4] = 150

SF

[HA] = 0.3

[HA] = 1.0

[HA] = 3.33

2C: PRG4 low, HA dose (N = 4)

PBS

[PRG4] = 45

[PRG4] = 45

[PRG4] = 45

SF

[HA] = 0.3

[HA] = 1.0

[HA] = 3.33

3: R/A PRG4, HA (N = 8)

PBS

[PRG4] = 0

R/A [PRG4] = 450

[PRG4] = 450

SF

[HA] = 3.33

[HA] = 3.33

[HA] = 3.33

4: PRG4, cross-linked HA (N = 8)

PBS

[PRG4] = 0

[PRG4] = 450

SF

N/A

[HYLAN G-F 20] = 3.33

[HYLAN G-F 20] = 3.33