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Table 1 Summary of lubricant sequences used over 4 – 5 consecutive days of testing

From: Cartilage boundary lubrication synergism is mediated by hyaluronan concentration and PRG4 concentration and structure

Test Lubricant [PRG4] (μg/mL), [HA] (mg/ml)
1 2 3 4 5
1A: PRG4 low dose, HA (N = 4) PBS [PRG4] = 4.5 [PRG4] = 45 [PRG4] = 150 SF
[HA] = 3.33 [HA] = 3.33 [HA] = 3.33
1B: PRG4 high dose, HA (N = 6) PBS [PRG4] = 150 [PRG4] = 450 [PRG4] = 1500 SF
[HA] = 3.33 [HA] = 3.33 [HA] = 3.33
2A: PRG4 high, HA dose (N = 8) PBS [PRG4] = 450 [PRG4] = 450 [PRG4] = 450 SF
[HA] = 0.3 [HA] = 1.0 [HA] = 3.33
2B: PRG4 mid, HA dose (N = 4) PBS [PRG4] = 150 [PRG4] = 150 [PRG4] = 150 SF
[HA] = 0.3 [HA] = 1.0 [HA] = 3.33
2C: PRG4 low, HA dose (N = 4) PBS [PRG4] = 45 [PRG4] = 45 [PRG4] = 45 SF
[HA] = 0.3 [HA] = 1.0 [HA] = 3.33
3: R/A PRG4, HA (N = 8) PBS [PRG4] = 0 R/A [PRG4] = 450 [PRG4] = 450 SF
[HA] = 3.33 [HA] = 3.33 [HA] = 3.33
4: PRG4, cross-linked HA (N = 8) PBS [PRG4] = 0 [PRG4] = 450 SF N/A
[HYLAN G-F 20] = 3.33 [HYLAN G-F 20] = 3.33