Fig. 3
From: The effects of zoledronate on the survival and function of human osteoblast-like cells
Zoledronate (ZOL) at the μM level presents a negative effect on matrix mineralization of MG-63 and G-292 cells. a Photographs of Alizarin red staining of differentiating MG-63 and G-292 cells on the 7th day showed a negative association between ZOL concentrations and the amount of bone nodule formation. b Sequential changes of the levels of type I collagen, alkaline phosphatase (ALP) and osteocalcin (OCN) of MG-63 and G-292 cells treated with ZOL. Data are mean ± standard deviation (SD). N = 3–5 for each experiment; *p < 0.05, **p < 0.001 (vs. the control group; ANOVA)