Study | Design | Risk of bias (Quality) | N | Popu-lation | Standing intervention | Time | Results |
---|---|---|---|---|---|---|---|
Adams & Hicks 2011 [28] | Randomized crossover | Serious risk (low quality) | 7 | Chronic SCI | Tilt table angle 68.6° ± 11.3 | 45 mins, 3 × wk × 4 weeks (135 mins/week) | Extensor spasms were reduced to a greater degree with standing than BWSTT. Flexor spasms, clonus, self-reported mobility, and QOL tended to benefit more from 4 weeks of BWSTT than standing alone |
Alekna et al. 2008 [29] | Longitudinal | Serious risk (low quality) | 54 total–27 matched pairs | Sub-acute SCI followed for 18 mos | Upright standing frame | 60 mins, 5 × wk (300 mins/week) | No SS difference between standing and non-standing groups in yr 1. After 2 years those standing >/=1 h daily, 5 days/week had SS higher leg BMD than non-standing group |
Allison & Dennett 2007 [30] | RCT | Moderate risk (moderate quality) | 17 | Sub-acute stroke | Upright stander | 45 mins, 5 × wk (225 mins/week) | Intervention group: SS improvement Berg Balance score between wk 1 and 12, in intervention group. Non SS higher scores on all motor measures wk 12 |
Bagley et al. 2005 [31] | RCT | Moderate risk (moderate quality) | 167 total–71 intervention, 69 controls | Sub-acute stroke | Upright standing frame | 26 mins × 14 sessions (182 mins/week) | No SS difference between groups on any outcome measure or decrease in resource use |
Baker et al. 2007 [32] | Randomized crossover | Moderate risk (moderate quality) | 6 | Chronic MS | Upright standing frame | 30 mins daily × 3 weeks (210 mins/week) | SS improvement in hip and ankle ROM in standing vs exercise phase for both groups. No SS differences in spasticity or spasm although downward trend seen |
Ben et al. 2001 [33] | RCT | Moderate risk (moderate quality) | 20 | Sub-acute SCI | Tilt-table, vertical | 30 mins, 3× wk × 12 weeks (90 mins/week) | Mean treatment effect on ankle ROM of 4° and on femur BMD of 0.005 |
Bohannon & Larkin 1985 [34] | Case series | Moderate risk (moderate quality) | 20 | Sub-acute and chronic SCI | Tilt table, 70° | 30 mins × 2.3–6.4 × wk (69–192 mins/week) | Passive ankle dorsiflexion ROM increases in all subjects of between 3 and 17° at a calculated rate of 0.11 to 1.0° a day |
Bohannon 1993 [35] | Case study | N/A (low quality) | 1 | Chronic SCI | Tilt table, 80° | 30 mins × 5 sessions (150 mins/week) | Each day’s standing trial followed by immediate reduction in lower extremity spasticity (modified Ashworth scale and pendulum testing). Spasms reduced until following morning-helpful for performance of car transfers |
Cotie et al. 2010 [36] | Randomized crossover | Moderate risk (moderate quality) | 7 | Chronic SCI | Tilt table, to maximum angle tolerated or 80° | 30 mins, 3 × wk × 4 weeks (90 mins/week) | Resting skin temperature decreased at 4 sites after 4 weeks BWSTT. Resting skin temp decreased at right thigh only after 4 weeks standing. Both BWSTT and standing training altered reactivity of skin temperature at all sites except the right calf following single session. 1 session BWSTT skin temperature decreased at 6 sites |
I session standing skin temperature decreased 2/6 sites | |||||||
De Bruin et al. 1999 [37] | SSRD—MBD | Serious risk (low quality) | 19 | Sub-acute SCI | Upright stander | 60 mins, 5 × wk (300 mins/week) | Marked decrease trabecular bone in the nonintervention subjects. Subjects beginning standing program early showed no or insignificant loss of trabecular bone |
Dunn et al. 1998 [38] | Cross-sectional survey | N/A (low quality) | 99 | Chronic SCI | Upright stander | 30–60 min 1–6×/week (30–360 mins/week) | Less than 10 % experienced side effects e.g. nausea or headaches 21 % reported being able to empty their bladder more completely. Favorable response on effects of the standing on bowel regularity, reduction of urinary tract infections, leg spasticity, and number of bed sores. 79 % of subjects highly recommended standing devices |
Edwards & Layne 2007 [39] | Case series | Serious risk (low quality) | 4 | Chronic SCI | Upright stander | 60 mins, 2 × wk × 12 weeks (120 mins/week) | Subjects actively responded to exercise in the standing device, as measured by EMG, HR, and BP |
Eng et al. 2001 [20] | Cross-sectional survey | N/A (low quality) | 126 | Chronic SCI | Upright stander or walker and long-leg braces | 40 min 3.8 ×/week (152 mins/week) | Reported improved well-being, circulation, self-care, skin integrity, reflex activity, bowel and bladder function, digestion, sleep, pain, and fatigue. The most common reason preventing respondents from standing was cost of standing equipment |
Eser et al. 2003 [40] | RCT | Serious risk (low quality) | 38 (19 in each group) | Sub-acute SCI | Passive standing angle or device not stated | 30 mins, 5 × wk (150 mins/week) | No SS difference between 30 mins FES cycling or 30 mins standing. Tibial cortical BMD decreased by 0–10 % of initial values within 3–10 mos. Mean decrease BMD 0.3 % per month FES group and 0.7 % in standing group |
Frey-Rindova et al. 2000 [41] | Longitudinal | Serious risk (low quality) | 29 | Sub-acute SCI followed for 2 years | Upright stander | 30 mins, 3 × wk (90 mins/week) | 12 mos after SCI: tetraplegic - SS decrease BMD in trabecular bone of radius and tibia; paraplegic - decrease in tibia BMD only. No SS influence of physical activity intensity. Tilt table standing in early rehabilitation may attenuate decrease of BMD of tibia in some |
Goemaere & Laere 1994 [42] | Cross-sectional | Moderate risk (moderate quality) | 53 | Chronic SCI | Upright stander | 60 mins, 3–7 × wk × 52 weeks (180–420 mins/week) | Standing group better-preserved BMD at femoral shaft (p = 0.009), but not at proximal femur, than non-standing. BMD at lumbar spine (L3, L4) marginally higher in standing group (SS only for L3). Subgroup standing with long leg braces SS higher BMD at proximal femur than those using a standing frame or wheelchair |
Goktepe et al. 2008 [43] | Cross-sectional | Moderate risk (moderate quality) | 71 | Chronic SCI | Upright stander | 60 mins daily (420 mins/week) | No SS difference in BMD found among mean t-scores of lumbar and proximal femoral regions of those standing > 1 h, < 1 h or non-standing. Standing >1 h daily -slight tendency to higher t-scores |
Hoenig & Murphy 2001 [44] | Case study | N/A (low quality) | 1 | Chronic SCI | Upright stander | 60 min 5 × wk (300 min/week) | Significant increase in frequency of bowel movements and decrease in bowel care time with use of standing table 5 times/week vs baseline |
Kim et al. 2015 [57] | RCT | Moderate risk (moderate quality) | 30 | Sub-acute stroke | Tilt table (subjects determined angle) | 20 min 5×/week (100 min) | SS increase in the strength of all LE muscle groups, gait velocity, cadence, stride length, decrease in double limb support period, and improvement in gait symmetry in task-oriented training on a tilt table group vs standing only or standing on 1 leg only groups. |
Kim et al. 2015 [58] | RCT | Moderate risk (moderate quality) | 39 | Sub-acute Stroke | Tilt table (subjects determined angle) | 20 min 5×/week (100 min/week) | SS increase in EMG patterns of affected leg extensors and flexors and clinical scores in standing with task-oriented training group vs controls or standing alone. SS improvement in functional status and lower extremity movement in tilt table standing group vs controls |
Kunkel et al. 1993 [45] | Case series | Serious risk (low quality) | 6 (4 SCI, 2 MS) | Chronic SCI and MS | Upright stander | 144 h over 135 days = 64 mins day × 7 (448 mins/week) | No important differences between initial and final scores for clinical assessment and ROM. 3 subjects for whom H-reflexes were found, latency and amplitude not altered by standing. BMD normal in lumbar spine but sig reduced in femoral neck. Standing did not modify BMD in any site. 67 % of subjects continued to “stand” and felt healthier because of it |
Kuznetsov et al. 2013 [46] | RCT | Serious risk (low quality) | 104 divided between 3 groups | Sub-acute stroke | 31 controls used tilt table, 60°–80° | 20–30 mins day × 30 days (140–210 mins/week) | Compared robotic tilt-table training (ROBO) plus FES vs ROBO vs tilt-table only (controls). 8 controls prematurely quit study due to orthostatic reactions. BP and cerebral blood flow dipped <10 % during ROBO. 52 % of controls - mean arterial pressure decreased by ≥20 %. ROBO-FES increased leg strength by 1.97 ± 0.88 points, ROBO by 1.50 ± 0.85 more than controls (1.03 ± 0.61, P < 0.05). Cerebral blood flow volume increased in ROBO groups more than controls (P < 0.05) |
Kwok 2015 [59] | Randomized Crossover | Moderate quality (moderate risk) | 17 | Chronic SCI | Tilt-table, as upright as possible | 30 mins day 5 × wk × 6 weeks (150 mins/week) | No difference in time to first stool or time for bowel care routine. 8/17 reported improved bowel function including decreased abdominal distention. Some participants reported decreased muscle tone, improved posture in wheelchair and sense of achievement. |
Lee et al. 1996 [47] | RCT | Serious risk (low quality) | 60 | Sub-acute stroke | Upright stander with/without biofeedback | 20 mins day × 2–4 weeks (140 mins/week) | SS improvement in static standing steadiness (p < 0.002) in group using biofeedback |
Matjacic et al. 2003 [48] | Case study | N/A (low quality) | 1 | Chronic stroke | Upright dynamic stander | 20 mins, 10 sessions (100 mins/week) | Subject demonstrated substantial functional improvement and improved weight-shifting ability following 10 days balance training in a specialized standing frame with computer feedback |
Nelson & Schau 1997 [49] | SSRD | Low risk (high quality) | 1 | Chronic CP | Upright stander | Work day | Small increase in work output when positioned in the standing table but dramatically improved posture |
Netz et al. 2007 [50] | Case series | Low risk (high quality) | 13 | Chronic - various | Upright standing box | Mean 16 mins, 47 sessions in 12 weeks. (62 mins/week) | Significant post-intervention improvements in LE muscle strength. Improvements measured with FIM in sphincter control, locomotion, mobility, motor score, and total score. Over 60 % of those previously requiring assistance to stand were able to stand for an average of 1 min unassisted and walk an average of 14 m with a walker |
Odeen & Knutsson 1981 [51] | Case series | Serious risk (low quality) | 9 | Chronic SCI | Tilt-table 85° Feet in 15° dorsal or plantar flexion | 30 mins × 8 sessions, 4 consecutive days (120–210 mins/week) | Following weight-bearing stretch in standing with feet in dorsal or plantar flexion, average reduction in resistance to passive movement was 32 % and 26 %, respectively. Following un-weighted stretch in supine, average reduction was 17 % |
Richardson 1991 [52] | SSRD | Serious risk (low quality) | 1 | Sub-acute TBI | Upright stander | 10 mins daily × 7 days (70 mins/week) | Subject increased tolerance for standing and ankle ROM increased |
Robinson et al. 2008 [53] | RCT | Low risk (high quality) | 30 | Sub-acute stroke | Upright stander | 30–40 mins × 5 days a wk × 4 weeks (150–200 mins/week) | Same ankle ROM at 4 and 10 week for 2 interventions: splint with affected ankle plantargrade, 7 nights wk vs tilt table standing with ankle at maximum dorsiflexion, 5 × wk |
Shields & Dudley-Javoroski 2005 [54] | Case study | N/A (low quality) | 1 | Chronic SCI | Standing wheelchair | 30–40 mins × 5 days a wk (130.4 mins/week) | Data-logger indicated client chose to stand for multiple short bouts (mean = 11.57 min) at average angle of 61° and average of 3.86 ×/week. He achieved 130.4 % of goal (20 mins 5 ×/week) resulting in average of 130.4 min/week. Subjective reports of improved spasticity and bowel motility |
Singer et al. 2004 [55] | Longitudinal | Unclear risk (low quality) | 105 | Acute TBI | Upright stander | 30 mins daily (210 mins/week) | Ankle contracture identified in 40/105 patients studied. In 23/40 contracture resolved with PT including prolonged weight-bearing stretches. 17/40 contracture worsened. 10/17 required serial plaster casting (+/− injection of botulinum toxin type A). Remediation of ankle contracture not a priority in 7/40 due to disability severity. Dystonic extensor muscle over-activity major contributor to persistent or progressive ankle contracture |
Taveggio et al. 2015 [60] | RCT | Moderate risk (moderate quality) | 8 | Sub-acute ABI in VS or MCS | Tilt table at 65° | 30 mins 3×/week × 24 sessions | Robotic stepping reduced cardiovascular distress in 3 out of 4 patients. Orthostatic hypotension worsened in 3 out of 4 patients in the static standing only group |
Walter et al. 1999 [22] | Cross-sectional Survey | N/A (low quality) | 99 | Chronic SCI | Upright stander | >30 min 7×/week (>210 mins/week) | Respondents (n = 99) who stood ≥30 min/day had sig improved QOL, fewer bed sores, fewer bladder infections, improved bowel regularity, and improved ability to straighten their legs compared with those who stood less time. Compliance with regular home standing (at least once per week) was high (74 %) |
Wong & Lee 1997 [56] | RCT | Serious risk (low quality) | 60 | Sub-acute stroke and TBI | Upright stander with/without biofeedback | 60 mins 5 × wk × 2–4 weeks (300 mins/week) | After 4 weeks, % postural asymmetry in intervention (with biofeedback) and controls was reduced from 17.2 +/− 10.8 % and 17.0 +/− 10.0 % to 3.5 +/− 2.2 % and 10.1 +/− 6.4%, respectively (p = 0.003) |