Table 1 Demographic data, clinical parameters at presentation, treatments given, and outcome data for all patients within the vasculitis service and also categorised by ANCA subtype
Characteristic | PR3+ (n = 51) | MPO+ (n = 46) | ANCA-a (n = 7) | Overall (n = 104) |
|---|---|---|---|---|
Age | 58 ± 15 | 64 ± 19 | 61 ± 4 | 61 ± 16 |
Male / Female | 26 /25 | 21 / 25 | 5 / 2 | 52 / 52 |
Renal involvement (%) | 45 (88) | 44 (96) | 4 (57) | 93 (89) |
At presentation | ||||
Creatinine (μmol/l) | 225 ± 225 | 330 ± 239 | 234 ± 216 | 272 ± 235 |
CRP (mg/l) | 97 ± 86 | 73 ± 73 | 38 ± 40 | 82 ± 79 |
Haemoglobin (g/l) | 107 ± 23 | 98 ± 18 | 114 ± 28 | 103 ± 22 |
Dialysis-requiring | 9 | 11 | 1 | 21 |
Induction period (~3 months) | ||||
Number (%) of patients receiving | ||||
Glucocorticoids | 51 (100) | 46 (100) | 7 (100) | 104 (100) |
CYC | 35 (69) | 30 (65) | 3 (43) | 68 (65) |
MMF | 9 (18) | 18 (39) | 2 (29) | 29 (28) |
Rituximab | 6 (12) | 15 (33) | 1 (14) | 22 (21) |
Plasma exchange | 25 (49) | 30 (65) | 3 (43) | 58 (56) |
Cumulative glucocorticoid dose (g) | 2.3 ± 0.3 | 2.4 ± 0.3 | 2.2 ± 0.0 | 2.3 ± 0.3 |
Cumulative CYC dose (g) | 6.5 ± 3.2 | 6.4 ± 3.9 | 5.3 ± 1.0 | 6.3 ± 3.4 |
Remission | ||||
Number entering remission (%) | 50 (98) | 44 (96) | 7 (100) | 101b (97) |
Time to remission (days) | 108 ± 184 | 82 ± 29 | 124 ± 149 | 98 ± 136 |
At 12 months | ||||
Creatinine (μmol/l) | 124 ± 57 | 215 ± 193 | 120 ± 68 | 158 ± 132 |
Dialysis-requiring | 1 | 4 | 0 | 5 |
Relapses & mortality | ||||
Number of patients with disease relapses (%) | 15 (29) | 4 (9) | 1 (14) | 20 (19) |
Mean time to first relapse (days) | 880 ± 692 | 1073 ± 877 | 635 ± 760 | 953 ± 786 |
Median time to first relapse (days & IQR) | 754 (823) | 857 (1252) | 223 (1078) | 795 (1102) |
Number of patients died (%) | 5 (10) | 4 (9) | 0 (0) | 9 (9) |