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Table 1 Demographic data, clinical parameters at presentation, treatments given, and outcome data for all patients within the vasculitis service and also categorised by ANCA subtype

From: Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a dedicated clinical service

Characteristic PR3+ (n = 51) MPO+ (n = 46) ANCA-a (n = 7) Overall (n = 104)
Age 58 ± 15 64 ± 19 61 ± 4 61 ± 16
Male / Female 26 /25 21 / 25 5 / 2 52 / 52
Renal involvement (%) 45 (88) 44 (96) 4 (57) 93 (89)
At presentation     
Creatinine (μmol/l) 225 ± 225 330 ± 239 234 ± 216 272 ± 235
CRP (mg/l) 97 ± 86 73 ± 73 38 ± 40 82 ± 79
Haemoglobin (g/l) 107 ± 23 98 ± 18 114 ± 28 103 ± 22
Dialysis-requiring 9 11 1 21
Induction period (~3 months)     
Number (%) of patients receiving     
Glucocorticoids 51 (100) 46 (100) 7 (100) 104 (100)
CYC 35 (69) 30 (65) 3 (43) 68 (65)
MMF 9 (18) 18 (39) 2 (29) 29 (28)
Rituximab 6 (12) 15 (33) 1 (14) 22 (21)
Plasma exchange 25 (49) 30 (65) 3 (43) 58 (56)
Cumulative glucocorticoid dose (g) 2.3 ± 0.3 2.4 ± 0.3 2.2 ± 0.0 2.3 ± 0.3
Cumulative CYC dose (g) 6.5 ± 3.2 6.4 ± 3.9 5.3 ± 1.0 6.3 ± 3.4
Remission     
Number entering remission (%) 50 (98) 44 (96) 7 (100) 101b (97)
Time to remission (days) 108 ± 184 82 ± 29 124 ± 149 98 ± 136
At 12 months     
Creatinine (μmol/l) 124 ± 57 215 ± 193 120 ± 68 158 ± 132
Dialysis-requiring 1 4 0 5
Relapses & mortality     
Number of patients with disease relapses (%) 15 (29) 4 (9) 1 (14) 20 (19)
Mean time to first relapse (days) 880 ± 692 1073 ± 877 635 ± 760 953 ± 786
Median time to first relapse (days & IQR) 754 (823) 857 (1252) 223 (1078) 795 (1102)
Number of patients died (%) 5 (10) 4 (9) 0 (0) 9 (9)
  1. ANCA anti-neutrophil cytoplasmic antibody, BVAS Birmingham Vasculitis Activity Score, EGPA eosinophilic granulomatosis with polyangiitis, ENT ear, nose & throat, GPA granulomatosis with polyangiitis, MPA microscopic polyangiitis, MPO myeloperoxidase, PR3 proteinase-3. Data are shown as number of patients (%), mean ± standard deviation or median and IQR. aThe 7 patients that were ANCA- had evidence of a pauci-immune necrotising glomerulonephritis on renal biopsy. b3 patients did not enter remission as they died during before this