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Table 1 Odds ratios for the association of antibodies to citrullinated peptides, their uncitrullinated controls, rheumatoid factor (RF) and RgpB, with pre-RA (n = 103). Conditional logistic regression was used with matched controls are referent (n = 309). Cut-off for antibody positivity is the 98th percentile of matched controls with the exception of anti-CCP2 and RF. RF; rheumatoid factor. CEP1, cFib and cVim; citrullinated peptides from α-enolase, fibrinogen and vimentin respectively. REP1, Fib and Vim are the arginine-containing control peptides. CPP3 and CPP5 are immunodominant peptides from PPAD, and RPP3 and RPP5 are the arginine-containing control peptides. RgpB; arginine gingipain

From: Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case–control study

Antibodies Controls n = 309 Pre-RA n = 103 Crude Fully adjusted model
  n (%) n (%) OR (95 % CI) p-value OR (95 % CI)a p-value
CCP2 10 (3) 24 (23) 9.94 (4.28–23.07) <0.001 9.46 (3.89–23.00) <0.001
RF 12 (4) 23 (22) 5.73 (2.79–11.76) <0.001 5.84 (2.66–12.86) <0.001
CEP1 6 (2) 15 (15) 7.11 (2.75–18.35) <0.001 7.26 (2.53–20.82) <0.001
REP1 6 (2) 2 (2) 0.77 (0.15–3.93) 0.748 1.17 (0.22–6.30) 0.853
cFIB 5 (2) 8 (18) 12.01 (4.06–35.55) <0.001 10.44 (3.39–32.10) <0.001
FIB 5 (2) 2 (2) 1.00 (0.19–5.19) 1.000 1.05 (0.20–0.57) 0.957
cVIM 3 (2) 5 (6) 2.84 (0.66–12.05) 0.157 4.84 (0.94–24.94) 0.059
VIM 5 (2) 4 (4) 2.00 (0.53–7.50) 0.304 2.47 (0.62–9.76) 0.199
CPP3 6 (2) 2 (2) 1.00 (0.20–4.95) 1.000 1.54 (0.28–8.31) 0.618
RPP3 5 (2) 5 (5) 2.88 (0.83–9.97) 0.095 3.76 (0.89–15.86) 0.071
CPP5 6 (2) 5 (5) 2.41 (0.73–7.91) 0.147 2.47 (0.71–8.54) 0.154
RPP5 5 (2) 2 (2) 1.20 (0.23–6.19) 0.827 1.78 (0.31–10.39) 0.521
RgpB 12 (4) 3 (3) 0.66 (0.17–2.62) 0.555 0.60 (0.15–2.46) 0.479
RGPB categories
  1 (<1280) 123 (44) 51 (50) ref - ref -
  2 (≥1280) 75 (27) 29 (28) 0.93 (0.54–1.60) 0.787 0.98 (0.55–1.77) 0.957
  3 (≥2560) 68 (24) 20 (19) 0.74 (0.39–1.38) 0.341 0.85 (0.44–1.68) 0.647
  4 (≥5120) 12 (4) 3 (3) 0.59 (0.14–2.45) 0.472 0.57 (0.13–2.44) 0.449
  1. a Adjusted for BMI, waist circumference, smoking, education, physical activity, and alcohol intake