Development and feasibility of a personalized, interactive risk calculator for knee osteoarthritis

Table 1 Model inputs

Input parameter	Possible values
Starting Age	25 years through 45 years
Sex	Female
Sex	Male
Race/ethnicity	White
	Black
	Hispanic
Obesity status	Obese
Obesity status	Non-obese
Family history	Family history
Family history	No family history
Occupational exposure	Present
Occupational exposure	Absent
History of knee injury	Present
History of knee injury	Absent
OA Incidence (annual probability, %)
Age Range	Non-obese male	Non-obese female	Obese Male	Obese Female
25–34	0.12	0.14	0.25	0.38
35–44	0.13	0.15	0.25	0.41
45–54	0.23	0.28	0.47	0.62
55–64	0.41	0.46	0.76	1.19
65–74	0.24	0.31	0.46	0.55
75–84	0.21	0.22	0.36	0.48
85+	0.21	0.22	0.36	0.48
OA Progression Estimates (annual probability, %)
			Male	Female
Progression from K-L 2 to K-L 3 (non-obese/obese)			5.58/ 12.26	4.00/ 8.95
Progression from K-L 3 to K-L 4 (non-obese/obese)			1.29/ 2.94	1.95/ 4.27
Risk Factors (multipliers for increased OA incidence, derived from Zhang et al. [33])
Knee injury	2.39
Family history of OA	1.72
Occupational risks	1.28

This table lists model input parameters and values used to create the 2016 simulations for OA Risk C

ISSN: 1471-2474