Table 1 Features of Hyaluronic Acids preparations tested
Commecial Name | Hyalgan® | Artrosulfur HA® | Hyalubrix® | Synolis-VA® |
|---|---|---|---|---|
Active Substance | Linear Sodium Hyaluronate | Linear Sodium Hyaluronate | Linear Sodium Hyaluronate | Linear Sodium Hyaluronate + Sorbitol (4 %) (limits the HA degradation) |
Molecular Weight | 600–730 KDa | 1000 KDa | 1600 KDa | 2000 KDa |
Source | Rooster Combs | Bacterial Fermentation | Bacterial Fermentation | Bacterial Fermentation |
Doses Tested | 250 μg/ml | 250 μg/ml | 1000 μg/ml | 1000 μg/ml |
500 μg/ml | 500 μg/ml | |||
1000 μg/ml | 1000 μg/ml | |||
Manufacturer | Fidia Farmaceutici s.p.a., Abano Terme (PD), Italy | Laborests.p.a., Nerviano (MI), Italy | Fidia Farmaceutici s.p.a. Abano Terme (PD), Italy | Anteis s.a., Geneva, Switzerland |