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Table 1 Differentially expressed genes in PC-treated and PC-E-treated cells compared with untreated cells

From: Disease-modifying effects of phosphocitrate and phosphocitrate-β-ethyl ester on partial meniscectomy-induced osteoarthritis

Biological process

Gene name

Gene ID

Differ Expre (fold)* PC

Differ Expre (fold)** PC-E

Description

Cell proliferation

     
 

BLM

NM_000057

−3.64

−1.78

Bloom syndrome

 

CCNE2

AF112857

−3.74

0.00

Cyclin E2

 

CCNE1

AI671049

−2.30

0.00

Cyclin E1

 

CDC25A

AY137580

−3.63

0.00

Cell division cycle 25 homolog A (S. pombe)

 

CDC25C

NM_001790

−2.31

0.00

Cell division cycle 25 homolog C (S. pombe)

 

CDC2

AA749427

−3.13

−3.42

Cell division cycle 2, G1 to S and G2 to M

 

CDC6

NM_001254

−2.36

−9.19

Cell division cycle 6 homolog (S. cerevisiae)

 

CDC7

NM_003503

−2.12

−4.42

Cell division cycle 7 homolog (S. cerevisiae)

 

CDCA3

NM_031299

−1.83

−2.61

Cell division cycle associated 3

 

CDCA5

BE614410

−2.41

−3.37

Cell division cycle associated 5

 

CDCA7

AY029179

−2.36

−4.60

Cell division cycle associated 7

 

CDCA8

BC001651

−2.11

−2.12

Cell division cycle associated 8

 

CDK2

AB012305

−2.74

−3.36

Cyclin-dependent kinase 2

 

NCAPH

D38553

−2.64

−2.21

Non-SMC condensin I complex, subunit H

 

HELLS

NM_018063

−2.49

−4.77

Helicase, lymphoid-specific

 

AURKB

AB011446

−2.43

0.00

Aurora kinase B

 

KIF23

AW192521

−2.41

−3.83

Kinesin family member 23

 

CLASP2

BC029035

−2.40

0.00

Cytoplasmic linker associated protein 2

 

NUF2

AF326731

−2.35

−4.04

NUF2, NDC80 kinetochore complex component, homolog

 

DSN1

NM_024918

−2.35

−3.09

DSN1, MIND kinetochore complex component, homolog

 

SPC24

AI469788

−2.32

0.00

SPC24, NDC80 kinetochore complex component, homolog

 

SPC25

AF225416

−2.10

−3.40

SPC25, NDC80 kinetochore complex component, homolog

 

HMGA2

AI990940

−2.30

−3.41

High mobility group AT-hook 2

 

LIG1

NM_000234

−2.25

−2.20

Ligase I, DNA, ATP-dependent

 

KIFC1

BC000712

−2.21

−2.08

Kinesin family member C1

 

BRCA2

X95152

−2.18

0.00

Breast cancer 2, early onset

 

ERCC6L

NM_017669

−2.17

−2.29

Exc repair cross-comp repair deficiency, comp group 6-like

 

SPAG5

NM_006461

−2.16

−2.61

Sperm associated antigen 5

 

NEK2

Z25425

−2.14

−2.20

NIMA (never in mitosis gene a)-related kinase 2

 

NCAPG

NM_022346

−2.12

−4.06

Non-SMC condensin I complex, subunit G

 

ZWINT

NM_007057

−2.01

−3.93

ZW10 interactor antisense

 

PARD3B

AF428251

3.24

1.68

Par-3 partitioning defective 3 homolog B (C. elegans)

 

11-Sep

AI333326

2.28

0.00

Septin 11

Angiogenesis

     
 

NRP1

AF280547

−2.69

0.00

Neuropilin 1

 

TEK

BF594294

−2.58

−1.73

TEK tyrosine kinase, endothelial

 

ELK3

NM_005230

−2.42

0.00

ELK3, ETS-domain protein (SRF accessory protein 2)

 

EREG

NM_001432

−1.90

0.00

Epiregulin

 

PML

AW291023

−1.89

0.00

Promyelocytic leukemia

 

COL15A1

NM_001855

−1.80

0.00

Collagen, type XV, alpha 1

 

NRP2

AI819729

−1.75

0.00

Neuropilin 2

 

SPHK1

NM_021972

−1.72

0.00

Sphingosine kinase 1

 

FOXC2

NM_005251

−1.68

0.00

Forkhead box C2 (MFH-1, mesenchyme forkhead 1)

 

SCG2

NM_003469

−1.66

2.54

Secretogranin II (chromogranin C)

 

EDNRA

NM_001957

−1.56

0.00

Endothelin receptor type A

 

TGFBR2

NM_003242

−1.51

−1.97

Transforming growth factor, beta receptor II (70/80 kDa)

 

ROBO4

AA156022

−1.51

0.00

Roundabout homolog 4, magic roundabout (Drosophila)

 

JAG1

AI457817

2.42

1.76

Jagged 1 (Alagille syndrome)

 

NOTCH4

AI341271

1.75

0.00

Notch homolog 4 (Drosophila)

 

RUNX1

D89788

1.73

0.00

Runt-related transcription factor 1

 

EPAS1

NM_001430

1.67

0.00

Endothelial PAS domain protein 1

Inflammatory response

     
 

PTGS2

AY151286

−6.09

0.00

Prostaglandin-endoperoxide synthase 2

 

SERPINA1

AF119873

−2.15

0.00

Serpin peptidase inhibitor, clade A

 

GPR68

AI805006

−2.15

−2.44

G protein-coupled receptor 68

 

BMPR1B

AA935461

−2.12

0.00

Bone morphogenetic protein receptor, type IB

 

EVI1

BE466525

−2.00

−1.69

Ecotropic viral integration site 1

 

FOS

BC004490

−1.92

1.51

V-fos FBJ murine osteosarcoma viral oncogene homolog

 

IRAK2

AI246590

−1.82

0.00

Interleukin-1 receptor-associated kinase 2

 

CCL2

S69738

−1.82

0.00

Chemokine (C-C motif) ligand 2

 

CCR1

NM_001295

−1.60

0.00

Chemokine (C-C motif) receptor 1

 

CXCL2

M57731

−1.66

0.00

Chemokine (C-X-C motif) ligand 2

 

SPN

BC035510

−1.79

0.00

Sialophorin (leukosialin, CD43)

 

TLR4

AF177765

−1.70

0.00

toll-like receptor 4

 

SCG2

NM_003469

−1.66

2.54

Secretogranin II (chromogranin C)

 

FN1

AJ276395

−1.58

−1.52

Fibronectin 1

 

KLKB1

BE326857

−1.52

0.00

Cytochrome P450, family 4, subfamily V, polypeptide 2

 

NDST1

NM_001543

2.05

0.00

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1

 

C3

NM_000064

2.05

0.00

Complement component 3

 

SERPINA3

NM_001085

1.88

0.00

Serpin peptidase inhibitor, clade A

 

SBNO2

AC005390

1.78

0.00

strawberry notch homolog 2 (Drosophila)

 

NFKBIZ

BE646573

1.74

0.00

NF-KB inhibitor zeta

 

MASP1

NM_001879

1.64

0.00

Mannan-binding lectin serine peptidase 1

 

STAT5B

NM_012448

1.59

0.00

Signal transducer and activator of transcription 5B

  1. *Negative number indicates decreased expression (fold) in treated hTERT-OA 13A FLS compared with untreated cells
  2. Positive number indicates elevated expression (fold) in treated hTERT-OA 13A FLS compared with the untreated cells
  3. **Dada was published previously [29]