Table 1 Subject characteristics
|  | All men (n = 194) | Middle-aged men (≤59 years of age, n = 98) | Older men (>59 years of age, n = 96) |
|---|---|---|---|
Age, years (mean, range) | 60.4 (51–81) | 55.6 (51–59)* | 65.4 (60–81)* |
Body mass index, kg/m2 (mean, range) | 29.2 (17.3–41.7) | 28.9 (18–38.5) | 29.5 (17.3–41.7) |
Osteoprotegerin, pmol/L (mean, range) | 5.0 (2.2–10.1) | 4.6 (2.2–7.7)** | 5.4 (3.0–10.1)** |
sRANKL, pmol/L (mean, range) (≥0.020 pmol/L detection limit) | 0.197 (0.020–0.875) (n = 120) | 0.226 (0.026–0.875)*** (n = 61) | 0.167 (0.020–0.795)*** (n = 59) |
sRANKL/Osteoprotegerin ratio (mean, range) | 0.043 (0.003–0.256) (n = 120) | 0.053 (0.006–0.256)**** (n = 61) | 0.033 (0.003–0.176)**** (n = 59) |
Total 17-β-Estradiol, nmol/L (mean, range) | 0.09 (0.02–0.19) | 0.09 (0.03–0.19) | 0.08 (0.02–0.15) |
Total testosterone, nmol/L (mean, range) | 12.8 (0.3–41.7) | 13.1 (2.7–41.7) | 12.4 (0.3–32.1) |
Sex hormone binding globulin, nmol/L (mean, range) | 40.8 (12.3–196.2) | 40.7 (12.7–196.2) | 40.9 (12.3–115.5) |
Free Estradiol Index (mean, range) | 0.0026 (0–0.009) | 0.0026 (0.001–0.007) | 0.0025 (0–0.009) |
Free testosterone Index (mean, range) | 0.3398 (0.005–0.743) | 0.354 (0.081–0.704)***** | 0.325 (0.005–0.743)***** |
PTH, pmol/L (mean, range) | 4.2 (1–10.2) | 4.2 (1–10.2) | 4.3 (1.6–8.3) |
25-hydroxy-vitamin D, nmol/L (mean, range) | 73.1 (11–185) | 72.1 (11–137) | 74.0 (14–185) |
Osteocalcin, μg/L (mean, range) | 14.6 (5–35) | 15.2 (5–33) | 14.0 (6–35) |
C-terminal telopeptides of type-I collagen, μg/L (mean, range) | 0.22 (0.01–0.77) | 0.24 (0.01–0.77) | 0.20 (0.04–0.70) |
PINP, μg/L (mean, range) | 38.3 (10.5–98.6) | 39.2 (10.5–98.6) | 37.3 (13.1–81.3) |
Cystatin C, mg/L (mean, range) | 0.697 (0.381–1.150) | 0.657 (0.381–1.060)****** | 0.736 (0.485–1.150)****** |
L1-L4 bone mineral density, gm/cm2 (mean ± SD) | 1.172 ± 0.185 | 1.148 ± 0.167 | 1.197 ± 0.199 |
Femur neck bone mineral density, gm/cm2 (mean ± SD) | 0.970 ± 0.137 | 0.980 ± 0.131 | 0.960 ± 0.142 |