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Table 4 Gene and allele frequencies of the polymorphisms studied in knee OA patients and controls

From: Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study

SNP

OA

Controls

P value*

OR

(95 % CI)

 

N (%)

N (%)

   

HIF1A (rs11549465)

     

CC

66 (94.2)

49 (74.2)

0.003

5.7

1.7–21.6

CT

4 (5.8)

17 (25.8)

0.003

0.2

0.05–0.60

TT

0 (0.0)

0 (0.0)

-

  

C

136 (97.0)

115 (87.1)

0.004

5.0

1.53–18.2

T

4 (3.0)

17 (12.9)

0.004

0.2

0.05–0.65

HIF1A (rs11549467)

     

GG

68 (97.1)

65 (98.5)

1.77

0.5

0.02–76.1

GA

2 (2.8)

1 (1.5)

1.77

1.9

0.13–54.6

AA

0 (0.0)

0 (0.0)

-

  

A

138 (98.5)

131 (99.2)

1.18

0.5

0.02–7.5

G

2 (1.5)

1 (0.8)

1.18

1.9

0.13–53.5

HIF1A (rs2057482)

     

TT

59 (84.3)

55 (83.3)

2.64

1.0

0.39–2.93

TC

11 (15.7)

11 (16.4)

2.64

0.9

0.34–2.54

CC

0 (0.0)

0 (0.0)

-

  

T

129 (92.1)

121 (91.6)

1.76

1.0

0.41–2.76

C

11 (7.9)

11 (8.4)

1.76

0.9

0.36–2.43

WISP1 (rs2929970)

     

GG

25 (35.7)

24 (36.4)

2.52

0.9

0.42–2.06

AG

37 (52.8)

33 (50.0)

2.52

1.0

0.49–2.39

AA

8 (11.5)

9 (13.6)

1.98

0.7

0.24–2.58

A

53 (37.8)

51 (38.6)

1.78

0.9

0.58–1.63

G

87 (62.2)

81 (61.4)

1.78

1.0

0.62–1.74

  1. OA Patients with knee osteoarthritis, OR Odds ratio, CI Confidence interval; *P value corrected by Bonferroni test, <0.05. Significant P values and OR are reported in bold