Polymorphic variation of hypoxia inducible factor-1 A (HIF1A) gene might contribute to the development of knee osteoarthritis: a pilot study

Table 2 Demographic, anthropometric and biochemical parameters of knee OA patients and control group

Parameters	Knee OA patients (N = 70)	Controls (N = 66)	P value
Male/Female (%)	11.4/88.5	10.6/89.4	0.87
Age (years)	55.8 ± 6.7	47.5 ± 6.6	< 0.00001
Weight (kg)	72.3 ± 14.5	68.8 ± 13.4	0.14
BMI (kg/m²)	29.8 ± 5.1	26.9 ± 4.6	0.0007
Glucose (mg/dL)	112.4 ± 43.4	102.4 ± 77.9	0.36
Total cholesterol (mg/dL)	203.0 ± 31.3	206.1 ± 60.3	0.74
Uric acid (mg/dL)	5.48 ± 1.18	6.28 ± 2.2	0.03

Data are expressed as means ± Standard deviation. P values were estimated using Student t test, α = 0.05. BMI Body-mass index = normal: 18.5–24.9; overweight: 25.0–29.9; obesity: ≥ 30.0. Normal values for glucose: 75–110 mg/dL; total cholesterol: <200 mg/dL; uric acid: 3.5–6.7 mg/dL. Significant P values are reported in bold

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