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Table 3 Summary information for seven tomato intervention studies that measured urate levels before and after intervention

From: Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares

Study

Total (n)

Age1 (years)

Urate Measurement

Start Urate2 (μmolL-1)

End Urate2 (μmolL-1)

P-value3

Intervention

All

M

F

Engelhard et al. (37)4

31

18

13

48 (30–73)

Serum

336.7 ± 14.3

349.2 ± 15.5

P > 0.05

Participants consumed 1 250 mg ‘Lyc-O-Mato’ tomato extract capsule per day for 8 weeks

Jacob et al. (38)

24

4

20

23 (19–27)

Plasma

221.4 ± 49.8

221.0 ± 45.9

P > 0.05

Participants consumed 250 mL tomato juice twice daily for 2 weeks5

Urinary (mg/mg Cr)

0.39 ± 0.2

0.52 ± 0.2

P < 0.05

Lee et al. (39)6

10

10

-

26

Plasma

348 ± 55

394 ± 407

P < 0.01

Participants consumed a single 150 g portion of tomato sauce

Todd et al. (40)4,8

34

13

21

52 (27–64)

Plasma

326.1 ± 73.9

329.1 ± 77.5

P > 0.05

Participants consumed 500 mL tomato juice per day for 4 weeks

Todd et al. (41)8

23

5

18

44 (24–61)

Plasma

280.5 ± 72.0

292.2 ± 67.0

P > 0.05

Participants consumed 500 mL tomato juice per day for 4 weeks

Abete et al. (36)

30

18

12

(18–50)

Serum

267.7 ± 53.5

261.7 ± 71.4

P > 0.05

Participants consumed 160 g tomato sauce per day for 4 weeks

Vinha et al. (42)

35

-

35

20 (18–25)

Plasma

207.6 ± 55.9

198.1 ± 46.4

P < 0.001

Participants consumed an ~90 g tomato each day before lunch for 4 weeks

  1. 1Average (range)
  2. 2Average ± standard deviation
  3. 3All P-values were obtained using a Paired Student’s t-test or one-way ANOVA to assess data for significant changes before and after intervention (P < 0.05 indicates significance)
  4. 4All participants had hypertension
  5. 5Participants were divided into two groups – data are shown for only 12 individuals (no demographic data were available)
  6. 6All participants were of Chinese ethnicity
  7. 7Measurement taken 48 h after tomato consumption
  8. 8All uric acid data was not published, data shown here was provided by the study authors directly