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Table 3 Summary information for seven tomato intervention studies that measured urate levels before and after intervention

From: Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares

Study Total (n) Age1 (years) Urate Measurement Start Urate2 (μmolL-1) End Urate2 (μmolL-1) P-value3 Intervention
All M F
Engelhard et al. (37)4 31 18 13 48 (30–73) Serum 336.7 ± 14.3 349.2 ± 15.5 P > 0.05 Participants consumed 1 250 mg ‘Lyc-O-Mato’ tomato extract capsule per day for 8 weeks
Jacob et al. (38) 24 4 20 23 (19–27) Plasma 221.4 ± 49.8 221.0 ± 45.9 P > 0.05 Participants consumed 250 mL tomato juice twice daily for 2 weeks5
Urinary (mg/mg Cr) 0.39 ± 0.2 0.52 ± 0.2 P < 0.05
Lee et al. (39)6 10 10 - 26 Plasma 348 ± 55 394 ± 407 P < 0.01 Participants consumed a single 150 g portion of tomato sauce
Todd et al. (40)4,8 34 13 21 52 (27–64) Plasma 326.1 ± 73.9 329.1 ± 77.5 P > 0.05 Participants consumed 500 mL tomato juice per day for 4 weeks
Todd et al. (41)8 23 5 18 44 (24–61) Plasma 280.5 ± 72.0 292.2 ± 67.0 P > 0.05 Participants consumed 500 mL tomato juice per day for 4 weeks
Abete et al. (36) 30 18 12 (18–50) Serum 267.7 ± 53.5 261.7 ± 71.4 P > 0.05 Participants consumed 160 g tomato sauce per day for 4 weeks
Vinha et al. (42) 35 - 35 20 (18–25) Plasma 207.6 ± 55.9 198.1 ± 46.4 P < 0.001 Participants consumed an ~90 g tomato each day before lunch for 4 weeks
  1. 1Average (range)
  2. 2Average ± standard deviation
  3. 3All P-values were obtained using a Paired Student’s t-test or one-way ANOVA to assess data for significant changes before and after intervention (P < 0.05 indicates significance)
  4. 4All participants had hypertension
  5. 5Participants were divided into two groups – data are shown for only 12 individuals (no demographic data were available)
  6. 6All participants were of Chinese ethnicity
  7. 7Measurement taken 48 h after tomato consumption
  8. 8All uric acid data was not published, data shown here was provided by the study authors directly