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Table 3 Adjusted relationships of tertiles of biomarkers to the TUGT and 4-m gait speeda

From: Relationship of anabolic and catabolic biomarkers with muscle strength and physical performance in older adults: a population-based cross-sectional study

 

Tertiles of biomarkers (Males)

Tertiles of biomarkers (Females)

 

Low

Middle

High

 

Low

Middle

High

 

Tertiles of CRP (range: mg/L)

0.02-0.31 (n =178)

0.31-0.93 (n = 179)

0.93-3.86 (n = 179)

p for trend b

0.01-0.42 (n = 198)

0.42-1.36 (n = 198)

1.36-4.74 (n = 199)

p for trend

No. of TUGT ≥ 13.5 s

15

16

39

-

28

29

35

-

 Crude

Ref

1.15 (0.55, 2.40) c

2.97 (1.6, 5.78)

<0.001

Ref

0.97 (0.55, 1.70)

1.26 (0.74, 2.17)

0.59

 Model 1

Ref

1.09 (0.51, 2.36)

2.58 (1.32, 5.23)

<0.01

Ref

0.63 (0.32, 1.20)

0.92 (0.49, 1.71)

0.41

 Model 2

Ref

1.11 (0.51, 2.44)

2.81 (1.41, 5.85)

<0.01

Ref

0.61 (0.31, 1.17)

0.91 (0.49, 1.71)

0.36

 Model 3

Ref

1.09 (0.50, 2.39)

2.7 (1.34, 5.66)

<0.01

Ref

0.58 (0.29, 1.12)

0.86 (0.46, 1.62)

0.33

Tertiles of IGF-1 (range: ng/mL)

18.1-81.8 (n =178)

81.8-95.1 (n = 179)

95.1-112.9 (n = 179)

 

5.87-82.5 (n =198)

82.5-93.8 (n = 196)

93.8-109.9 (n = 201)

 

No. of TUGT ≥ 13.5 s

26

20

24

-

41

19

32

-

 Crude

Ref

0.67 (0.35, 1.25)

0.88 (0.48, 1.59)

0.62

Ref

0.43 (0.24, 0.76)

0.72 (0.43, 1.19)

0.01

 Model 1

Ref

0.86 (0.44, 1.66)

1.24 (0.65, 2.38)

0.62

Ref

0.65 (0.33, 1.23)

1.19 (0.64, 2.2)

0.14

 Model 2

Ref

0.84 (0.42, 1.66)

1.29 (0.66, 2.53)

0.53

Ref

0.61 (0.31, 1.18)

1.19 (0.65, 2.22)

0.10

 Model 3

Ref

0.85 (0.42, 1.72)

1.27 (0.65, 2.49)

0.60

Ref

0.60 (0.30, 1.17)

1.12 (0.60, 2.11)

0.14

Tertiles of DHEAS (range: ug/dL)

21.2-0.31 (n =178)

0.31-0.93 (n = 179)

0.93-3.86 (n = 179)

 

12.4-50.1 (n = 198)

50.1-91.7 (n = 198)

91.7-150.8 (n = 199)

 

No. of TUGT ≥ 13.5 s

34

20

16

-

39

22

31

-

 Crude

Ref

0.54 (0.29, 0.97)

0.42 (0.22, 0.78)

<0.05

Ref

0.54 (0.31, 0.94)

0.73 (0.43, 1.23)

0.06

 Model 1

Ref

0.89 (0.46, 1.7)

0.75 (0.37, 1.48)

0.68

Ref

0.65 (0.34, 1.2)

1.09 (0.6, 1.98)

0.15

 Model 2

Ref

0.88 (0.45, 1.69)

0.73 (0.36, 1.47)

0.64

Ref

0.64 (0.34, 1.2)

1.06 (0.58, 1.95)

0.15

 Model 3

Ref

0.93 (0.47, 1.82)

0.73 (0.35, 1.47)

0.64

Ref

0.71 (0.37, 1.33)

1.09 (0.59, 2.01)

0.25

Tertiles of CRP (range: mg/L)

0.02-0.31 (n =146)

0.31-0.93 (n = 147)

0.93-3.86 (n = 135)

 

0.01-0.42 (n = 181)

0.42-1.36 (n = 165)

1.36-4.74 (n = 164)

 

No. of 4 m gait speed < 0.8 m/s

14

15

29

-

30

31

27

-

 Crude

Ref

1.09 (0.50, 2.37)

2.6 (1.33, 5.30)

<0.01

Ref

1.08 (0.62, 1.89)

0.97 (0.55, 1.7)

0.82

 Model 1

Ref

1.13 (0.51, 2.55)

2.43 (1.18, 5.19)

<0.05

Ref

0.76 (0.40, 1.43)

0.77 (0.41, 1.44)

0.72

 Model 2

Ref

1.26 (0.56, 2.89)

2.88 (1.36, 6.37)

<0.05

Ref

0.74 (0.39, 1.39)

0.75 (0.4, 1.4)

0.65

 Model 3

Ref

1.25 (0.55, 2.88)

2.84 (1.33, 6.33)

<0.05

Ref

0.72 (0.37, 1.37)

0.72 (0.37, 1.37)

0.59

Tertiles of IGF-1 (range: ng/mL)

18.1-81.8 (n =124)

81.8-95.1 (n = 159)

95.1-112.9 (n = 145)

 

5.87-82.5 (n =153)

82.5-93.8 (n = 175)

93.8-109.9 (n = 182)

 

No. of 4 m gait speed < 0.8 m/s

19

18

21

-

29

22

37

-

 Crude

Ref

0.63 (0.31, 1.26)

0.9 (0.46, 1.75)

0.57

Ref

0.68 (0.37, 1.22)

1.05 (0.61, 1.82)

0.13

 Model 1

Ref

0.73 (0.35, 1.52)

1.2 (0.59, 2.47)

0.49

Ref

0.88 (0.46, 1.70)

1.31 (0.70, 2.47)

0.24

 Model 2

Ref

0.73 (0.34, 1.54)

1.23 (0.59, 2.59)

0.46

Ref

0.94 (0.48, 1.82)

1.36 (0.72, 2.6)

0.26

 Model 3

Ref

0.73 (0.34, 1.55)

1.21 (0.58, 2.56)

0.48

Ref

0.92 (0.46, 1.82)

1.14 (0.59, 2.23)

0.59

Tertiles of DHEAS (range: ug/dL)

21.2-0.31 (n =130)

0.31-0.93 (n = 142)

0.93-3.86 (n = 156)

 

12.4-50.1 (n = 166)

50.1-91.7 (n = 169)

91.7-150.8 (n = 175)

 

No. of 4 m gait speed < 0.8 m/s

24

19

15

-

39

21

28

-

 Crude

Ref

0.68 (0.35, 1.30)

0.47 (0.23, 0.94)

0.10

Ref

0.49 (0.27, 0.87)

0.6 (0.35, 1.04)

<0.05

 Model 1

Ref

0.98 (0.49, 1.98)

0.72 (0.34, 1.49)

0.62

Ref

0.64 (0.34, 1.19)

0.86 (0.47, 1.57)

0.26

 Model 2

Ref

0.95 (0.46, 1.95)

0.7 (0.32, 1.47)

0.60

Ref

0.62 (0.33, 1.16)

0.81 (0.44, 1.49)

0.23

 Model 3

Ref

1.01 (0.48, 2.09)

0.68 (0.31, 1.44)

0.52

Ref

0.74 (0.38, 1.41)

0.86 (0.46, 1.62)

0.52

  1. Model 1: adjusted for age and BMI
  2. Model 2: adjusted for age, BMI, smoking status, and drinking status
  3. Model 3: adjusted for age, BMI, smoking status, drinking status, physical activity and family history of cardiovascular disease, hypertension, diabetes, and cancer
  4. aBMI body mass index, TUGT timed up and go test, CRP C-reactive protein, IGF-1 Insulin-like growth factor-1, DHEAS dehydroepiandrosteronesulphate
  5. bAnalysis by multiple logistic regression analysis
  6. cValues are expressed as odds ratios (95 % confidence interval) (all such values)
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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