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Table 2 Serological, clinical, and functional parameters during the five year study period

From: Predictors of response and drug survival in ankylosing spondylitis patients treated with infliximab

  Variable ESR CRP BASFI BASDAI BASMI VAS VASg
(mean ± SD)
Responders 0 M 21.7 ± 18.2 1.9 ± 1.6 47.1 ± 16.8 59.5 ± 15.3 5.9 ± 1.3 64.9 ± 16.9 50.5 ± 21.4
3 M 13.5 ± 12.8 1.3 ± 1.9 44.5 ± 17.5 54.2 ± 17.3 5.7 ± 1.4 61.3 ± 15.1 45.4 ± 22.1
6 M 10.4 ± 8.8 1.0 ± 1.4 38.1 ± 22.2 46.5 ± 20.1*** 5.6 ± 1.3 55.3 ± 12.4* 40.6 ± 21.6*
12 M 11.9 ± 12.4 1.1 ± 1.4 32.1 ± 20.1** 40.9 ± 19.4* 5.1 ± 1.6*** 41.1 ± 11.9* 35.6 ± 19.9*
24 M 10.9 ± 10.2 1.2 ± 1.9 27.2 ± 17.4* 38.9 ± 20.9* 4.8 ± 1.4* 37.8 ± 10.9* 32.4 ± 17.8*
36 M 14.2 ± 12.6 0.9 ± 1.1 23.4 ± 15.3* 31.4 ± 18.1* 4.7 ± 1.4* 36.2 ± 10.1* 30.5 ± 18.7*
48 M 13.1 ± 8.1 0.7 ± 1.6* 20.4 ± 13.9* 28.2 ± 18.8* 4.5 ± 1.3* 32.6 ± 12.1* 25.2 ± 19.6*
60 M 11.5 ± 8.8 0.8 ± 1.5* 15.8 ± 12.2* 25.8 ± 18.6* 4.2 ± 1.4* 30.8 ± 13.2 20.3 ± 19.8
  p 0.087 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001
Non-responders 0 M 31.0 ± 25.1 1.6 ± 1.5 52.2 ± 25.1 59.9 ± 19.6 5.4 ± 1.6 62.9 ± 18.8 61.1 ± 19.0
3 M 22.2 ± 22.6 1.4 ± 1.7 45.5 ± 21.9 55.7 ± 19.1 5.3 ± 1.6 57.2 ± 22.3 59.2 ± 22.9
6 M 21.5 ± 7.1 1.4 ± 1.6 43.2 ± 23.1 53.7 ± 19.9 5.0 ± 1.4 55.4 ± 20.6 60.5 ± 21.1
12 M 22.5 ± 20.4 1.4 ± 1.4 37.1 ± 24.9 23.0 ± 43.9 4.8 ± 1.6 47.8 ± 21.3 49.2 ± 20.0
24 M 17.9 ± 12.9 1.5 ± 3.1 24.9 ± 15.6 39.1 ± 25.6 4.9 ± 1.4 49.7 ± 22.2 55.5 ± 22.0
36 M 22.3 ± 14.1 1.4 ± 1.3 39.6 ± 27.9 38.8 ± 26.9 4.2 ± 2.2 50.2 ± 18.8 52.4 ± 19.7
48 M 23.5 ± 22.7 1.4 ± 2.1 33.4 ± 25.5 35.1 ± 23.3 4.1 ± 1.4 57.3 ± 17.4 60.6 ± 20.1
60 M 21.9 ± 15.8 1.6 ± 2.3 45.5 ± 25.1 43.1 ± 21.7 4.1 ± 1.5 58.2 ± 18.5 65.1 ± 19.8
  1. ESR Erytrocyte Sedimentation Rate, CRP C-Reactive Protein, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, BASFI Bath Ankylosing Spondylitis Functional Index, BASMI Bath Ankylosing Spondilitis Metrology Index, VAS pain Visual Analogue Scale pain, VASg Visual Analogue Scale global disease activity
  2. Data are expressed as mean ± SD. The Friedman repeated measures test and Dunn's multiple comparison test were used * p < 0.0001 vs T0, **p < 0.001 vs T0, ***p < 0.01 vs T0