Fig. 5

Bone response at the endocortical surface. (a) Formation perimeter (F.Pm); (b) mineral apposition rate (MAR); (c) bone formation rate (BFR). External loading exerted a significant effect on all three parameters (P < 0.001 by repeated two-way analysis of variance). F.Pm and MAR in the high-dose eldecalcitol (ED-H) group were highest among the four groups at both loaded and non-loaded tibiae; however, the differences with the vehicle (VEH) group were not significant compared by Dunnett’s test. BFR in the ED-H group was significantly higher than in the VEH group (P = 0.019, by Dunnett’s test), and the interaction between loading and the effects of eldecalcitol was significant (P = 0.043 by repeated two-way analysis of variance). Data are mean ± SEM. ED-H: high dose eldecalcitol; ED-M: medium dose eldecalcitol, ED-L; low dose eldecalcitol; VEH: vehicle