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Table 3 Changes of biochemistries for the intervertebral discs

From: Quantitative T2 relaxation time and magnetic transfer ratio predict endplate biochemical content of intervertebral disc degeneration in a canine model

  

PO

4 W

8 W

12 W

Uronic acid content

NP

1.59 ± 0.12

1.49 ± 0.13**

1.17 ± 0.14*,**,***

0.94 ± 0.11*,***

(μg/mg dry weight)

AF

0.52 ± 0.06

0.48 ± 0.04**

0.41 ± 0.07*,**,***

0.34 ± 0.03*,***

 

CEPZ

0.72 ± 0.08

0.69 ± 0.05**

0.62 ± 0.06*,**,***

0.56 ± 0.07*,***

Hydroxyproline

NP

0.41 ± 0.06

0.47 ± 0.05*,**

0.51 ± 0.05*,**,***

0.57 ± 0.03*,***

(μg/mg dry weight)

AF

0.80 ± 0.08

0.89 ± 0.08*,**

0.97 ± 0.09*,**,***

1.05 ± 0.94*,***

 

CEPZ

0.55 ± 0.08

0.51 ± 0.06**

0.45 ± 0.05*,**

0.40 ± 0.05*

Water content

NP

82.62 ± 4.70

80.83 ± 3.11**

76.04 ± 3.85*,**,***

71.43 ± 2.98*,***

(%)

AF

75.46 ± 4.07

72.95 ± 3.96**

67.17 ± 4.56*,**,***

62.29 ± 3.24*,***

 

CEPZ

79.75 ± 4.23

78.48 ± 3.18**

73.72 ± 3.72*,**,***

69.07 ± 3.59*,***

  1. *P < 0.05, compared to PO (pre-operation), of AF (annulus fibrous), NP (nucleus pulposus), and CEPZ (cartilage endplate zone) in uronic acid, hydroxyproline and water content, separately; **P < 0.05, compared to 12 W, of AF, NP, and CEPZ in uronic acid, hydroxyproline and water content, separately; ***P < 0.05, compared to 4 W, of AF, NP, and CEPZ in uronic acid, hydroxyproline and water content, separately. The units for the NP, AF, and CEPZ results are μg of epitope/mg of uronic acid or μg of epitope/mg of hydroxyproline, as appropriate for proteoglycans (PG) and the collagen contents