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Table 1 Descriptive baseline characteristics of Greek patients enrolled in ExFOS and EFOS

From: Teriparatide use during an economic crisis: baseline data from the Greek cohort of the Extended Forsteo Observational Study (ExFOS)

Greek population ExFOS total population ExFOS males ExFOS females EFOS [12]
Enrolment period (dates of first and last patient enrolment) 16 Feb 2011 – 24 May 2012 // // 05 Jul 2004 – 30 Sep 2005
Enrolment rate (patients/site/month) 0.95 // // 0.65
Number of patients (% women) 439 (92.3) 34 405 302 (100)
Mean (SD) age (years) 70.1 (9.8) 71.5 (10.3) 70.0 (9.8) 70.0 (8.5)
Mean (SD) BMI (kg/m2) 26.7 (4.3) 26.4 (4.6) 26.7 (4.3) 26.3 (4.0)
Menstrual history
Mean (SD) time since menopause (years) - - 22.1 (10.3) 24.4 (9.0)
Mean (SD) fertile period (years) - - 34.6 (5.6) 32.4 (5.9)
Early menopause before age 40 years (% patients) - - 5.5 9.3
Fracture risk factors (% patients)
Current smokers 12.1 33.3 10.4 12.6
No exercise 49.2 61.8 48.1 71.5
Hip fracture in biological mother 18.1 14.8 18.4 16.6
One or more falls in the preceding year 37.1 50.0 36.0 40.7
Assist standing using arms 41.3 58.8 39.8 92.1
Bone health
Mean (SD) DXA BMD spine −3.4 (0.7) −3.3 (1.3) −3.4 (0.7) 3.4 (0.7)
Mean (SD) DXA BMD total hip (higher N included) −3.2 (0.5) −3.4 (0.6) −3.2 (0.5) 2.8 (1.1)
Mean (SD) DXA BMD femoral neck (higher N included) −2.8 (1.2 −3.0 (0.4) −2.8 (1.2) 3.1 (0.8)
Fracture history (% patients) 55.1 70.6 53.8 74.5 a
Mean (SD) fracture number (for patients with at least one fracture) 1.7 (1.1) 2.0 (1.9) 1.7 (1.0) 1.8 (1.4)
Patients with vertebral fractures (% patients) 38.7 50 37.8 59.6 b
Patients with vertebral fractures (% of patients with fractures) 70.2 70.8 70.2 85.9
Patients with hip fractures (% of patients with fractures) 8.3 20.8 6.9 2.7
Prior treatments (% patients)
Prior anti-osteoporotic treatments 80.2 55.9 82.2 83.1
Calcitonin 23.2c 5.9 24.7 64.6
Bisphosphonates 59.0c 32.4 61.2 36.1
Prior glucocorticoid use 8.9c 17.6 8.1 14.6
Back pain and quality of life variables
Back pain in the previous year (% patients) 88.4 76.5 89.4 97.4
Moderate to severe pain in the month before enrolment (% patients) 80.9 88.0 80.4 85.3
Mean (SD) EQ-5D VAS (cm) 57.0 (21.7) 56.9 (20.7) 57.0 (21.8) 54.2 (24.9)
  1. aIn EFOS, 15.9 % of patients did not have a fracture history and data were missing for 9.6 % of patients
  2. In ExFOS, 44.9 % of patients did not have a fracture history
  3. b Data on file
  4. cPercentage of all patients enrolled
  5. BMD, bone mineral density BMI, body mass index; DXA, dual-energy X-ray absorptiometry; EFOS, European Forsteo Observational Study; ExFOS, Extended Forsteo Observational Study; SD, standard deviation, VAS, visual analogue scale