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Fig. 2 | BMC Musculoskeletal Disorders

Fig. 2

From: Developing an animal model of Dupuytren’s disease by orthotopic transplantation of human fibroblasts into athymic rat

Fig. 2

Imaging of human fibroblasts transplanted to nude rat forepaws shows cellular persistence for 62 days. Non-invasive in vivo imaging of the forepaws receiving DiR labeled CT-and DD-derived fibroblasts showed persistence of both populations of cells to 62 days (n = 6). The emitted fluorescent signal gradually declined over time for both cell types, but at day 62 DD-cells showed a significantly greater presence than CT-cells. (a) A representative image of the emitted fluorescent signals over time. Animals were injected with DD-derived fibroblasts in the left forepaw and with CT-derived fibroblasts on the right forepaw. (b) Quantitative assessment of emitted fluorescent signal over time, with day 5 set at 100 % of total flux. Statistical analyses using ANOVA showed a significant difference in the intensity of persisting fluorescence signal over time between the forepaw that received CT- and DD-derived fibroblasts. p value was < 0.0001

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