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Table 4 Significant changes in circulating biomarker concentrations, stratified at 6 months

From: Circulating anti-citrullinated peptide antibodies, cytokines and genotype as biomarkers of response to disease-modifying antirheumatic drug therapy in early rheumatoid arthritis

SDAI category ≤ 11
Variable n Baseline 6 months P value
Median IQR Median IQR
SDAI 43 32.42 24.71 6.40 5.34 0.0001
CRP (μg/ml) 43 9.50 20.80 6.90 8.10 0.0054
ACPA (IU/ml) 30 936.55 1162.70 344.60 671.80 0.0005
IL-4 (pg/ml) 9 7.50 7.30 1.50 4.00 0.0280
IL-7 (pg/ml) 36 22.22 82.20 16.19 16.74 0.0050
IL-8 (pg/ml) 36 8.05 11.48 5.56 6.15 0.0169
IL-10 (pg/ml) 9 13.30 15.25 6.85 5.64 0.0382
G-CSF (pg/ml) 36 21.99 99.56 5.78 55.94 0.0095
VEGF (pg/ml) 36 154.96 442.84 98.62 158.33 0.0036
SDAI category > 11 ≤ 26
Variable n Baseline 6 months P value
Median IQR Median IQR
SDAI 62 42.25 23.39 17.15 6.86 0.0001
CRP (μg/ml) 62 26.50 45.60 8.90 17.00 0.0001
ACPA (IU/ml) 42 483.35 1025.50 252.15 564.70 0.0001
IL-4 (pg/ml) 14 4.08 13.73 2.53 8.47 NS
IL-7 (pg/ml) 55 19.18 61.68 18.17 26.61 NS
IL-8 (pg/ml) 55 8.94 8.92 5.85 6.99 0.0029
IL-10 (pg/ml) 14 14.07 39.13 19.18 19.91 NS
G-CSF (pg/ml) 55 9.45 42.11 7.23 51.61 NS
VEGF (pg/ml) 55 168.10 420.05 84.30 169.40 0.0102
SDAI Category >26
Variable n Baseline 6 months P value
Median IQR Median IQR
SDAI 35 43.00 28.50 36.21 11.91 NS
CRP (μg/ml) 35 13.00 44.30 17.00 24.40 NS
ACPA (IU/ml) 28 353.60 917.00 177.00 714.40 NS
IL-4 (pg/ml) 9 1.24 7.18 0.62 1.0 NS
IL-7 (pg/ml) 32 46.67 113.17 13.66 32.18 0.0301
IL-8 (pg/ml) 32 8.55 27.69 6.37 14.49 NS
IL-10 (pg/ml) 9 5.76 8.93 5.81 2.97 NS
G-CSF (pg/ml) 32 11.7 39.12 9.87 54.15 NS
VEGF (pg/ml) 32 170.78 484.05 126.02 187.48 NS