Table 4 Significant changes in circulating biomarker concentrations, stratified at 6Â months
SDAI category ≤ 11 | ||||||
|---|---|---|---|---|---|---|
Variable | n | Baseline | 6 months | P value | ||
Median | IQR | Median | IQR | |||
SDAI | 43 | 32.42 | 24.71 | 6.40 | 5.34 | 0.0001 |
CRP (μg/ml) | 43 | 9.50 | 20.80 | 6.90 | 8.10 | 0.0054 |
ACPA (IU/ml) | 30 | 936.55 | 1162.70 | 344.60 | 671.80 | 0.0005 |
IL-4 (pg/ml) | 9 | 7.50 | 7.30 | 1.50 | 4.00 | 0.0280 |
IL-7 (pg/ml) | 36 | 22.22 | 82.20 | 16.19 | 16.74 | 0.0050 |
IL-8 (pg/ml) | 36 | 8.05 | 11.48 | 5.56 | 6.15 | 0.0169 |
IL-10 (pg/ml) | 9 | 13.30 | 15.25 | 6.85 | 5.64 | 0.0382 |
G-CSF (pg/ml) | 36 | 21.99 | 99.56 | 5.78 | 55.94 | 0.0095 |
VEGF (pg/ml) | 36 | 154.96 | 442.84 | 98.62 | 158.33 | 0.0036 |
SDAI category > 11 ≤ 26 | ||||||
Variable | n | Baseline | 6 months | P value | ||
Median | IQR | Median | IQR | |||
SDAI | 62 | 42.25 | 23.39 | 17.15 | 6.86 | 0.0001 |
CRP (μg/ml) | 62 | 26.50 | 45.60 | 8.90 | 17.00 | 0.0001 |
ACPA (IU/ml) | 42 | 483.35 | 1025.50 | 252.15 | 564.70 | 0.0001 |
IL-4 (pg/ml) | 14 | 4.08 | 13.73 | 2.53 | 8.47 | NS |
IL-7 (pg/ml) | 55 | 19.18 | 61.68 | 18.17 | 26.61 | NS |
IL-8 (pg/ml) | 55 | 8.94 | 8.92 | 5.85 | 6.99 | 0.0029 |
IL-10 (pg/ml) | 14 | 14.07 | 39.13 | 19.18 | 19.91 | NS |
G-CSF (pg/ml) | 55 | 9.45 | 42.11 | 7.23 | 51.61 | NS |
VEGF (pg/ml) | 55 | 168.10 | 420.05 | 84.30 | 169.40 | 0.0102 |
SDAI Category >26 | ||||||
Variable | n | Baseline | 6 months | P value | ||
Median | IQR | Median | IQR | |||
SDAI | 35 | 43.00 | 28.50 | 36.21 | 11.91 | NS |
CRP (μg/ml) | 35 | 13.00 | 44.30 | 17.00 | 24.40 | NS |
ACPA (IU/ml) | 28 | 353.60 | 917.00 | 177.00 | 714.40 | NS |
IL-4 (pg/ml) | 9 | 1.24 | 7.18 | 0.62 | 1.0 | NS |
IL-7 (pg/ml) | 32 | 46.67 | 113.17 | 13.66 | 32.18 | 0.0301 |
IL-8 (pg/ml) | 32 | 8.55 | 27.69 | 6.37 | 14.49 | NS |
IL-10 (pg/ml) | 9 | 5.76 | 8.93 | 5.81 | 2.97 | NS |
G-CSF (pg/ml) | 32 | 11.7 | 39.12 | 9.87 | 54.15 | NS |
VEGF (pg/ml) | 32 | 170.78 | 484.05 | 126.02 | 187.48 | NS |