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Table 3 Summary of predominant subclasses in autoantibodies in IgG4-RD and autoimmune diseases

From: Screening for IgG4-type anti-nuclear antibodies in IgG4-related disease

Diseases Autoantibodies Predominant subclass IgG4 subclass Reports
IgG4-RD ANA IgG2 Negative Present study
IgG4-RD (AIP) Anti-PSTI IgG1 Negative Asada [16]
SLE, SSc, SS, PM ANA IgG1/2/3 Seldom Present study, Zouali [11], Eisenberg [12], Maran [13], Vazquez-abad [14]
GPA, Vasculitis ANCA IgG1, IgG4 Frequent Brouwer [21], Mellbye [23], Liu [24], Gao [22]
RA ACPA IgG1, IgG4 Frequent Engelmann [25]
PF, PV Anti-Dsg-1/3 IgG4 Primary Rock [18], Ding [19]
Idiopathic MN Anti-PLA2R IgG4 Primary Beck [20]
  1. ACPA: anti-citrullinated protein antibody; AIP: autoimmune pancreatitis; ANA: anti-nuclear antibody; ANCA: anti-neutrophil cytoplasmic antibody; Dsg-1/3: desmoglein-1 and 3; GPA: granulomatosis with polyangiitis; MN: membranous nephropathy; PF: pemphigus foliaceus; PLA2R: phospholipase A2 receptor; PSTI: pancreatic secretory trypsin inhibitor; PV: pemphigus vulgaris; RA: rheumatoid arthritis