Screening for IgG4-type anti-nuclear antibodies in IgG4-related disease

Table 3 Summary of predominant subclasses in autoantibodies in IgG4-RD and autoimmune diseases

Diseases	Autoantibodies	Predominant subclass	IgG4 subclass	Reports
IgG4-RD	ANA	IgG2	Negative	Present study
IgG4-RD (AIP)	Anti-PSTI	IgG1	Negative	Asada [16]
SLE, SSc, SS, PM	ANA	IgG1/2/3	Seldom	Present study, Zouali [11], Eisenberg [12], Maran [13], Vazquez-abad [14]
GPA, Vasculitis	ANCA	IgG1, IgG4	Frequent	Brouwer [21], Mellbye [23], Liu [24], Gao [22]
RA	ACPA	IgG1, IgG4	Frequent	Engelmann [25]
PF, PV	Anti-Dsg-1/3	IgG4	Primary	Rock [18], Ding [19]
Idiopathic MN	Anti-PLA₂R	IgG4	Primary	Beck [20]

ACPA: anti-citrullinated protein antibody; AIP: autoimmune pancreatitis; ANA: anti-nuclear antibody; ANCA: anti-neutrophil cytoplasmic antibody; Dsg-1/3: desmoglein-1 and 3; GPA: granulomatosis with polyangiitis; MN: membranous nephropathy; PF: pemphigus foliaceus; PLA₂R: phospholipase A₂ receptor; PSTI: pancreatic secretory trypsin inhibitor; PV: pemphigus vulgaris; RA: rheumatoid arthritis

ISSN: 1471-2474