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Table 1 Clinical, serological, and histopathological features of IgG4-RD cases

From: Screening for IgG4-type anti-nuclear antibodies in IgG4-related disease

Case Age IgG4a IgGa ANA Specific Abs RFb Clinical manifestations Biopsy source, IgG4+/IgG+ cell ratio
1 73 2890 3668 40 (Homo + Spe) <6 Mikulicz’s disease, Prostatitis, LN Prostate, 0.60
2 76 2210 3632 40 (Spe) <6 Mikulicz’s disease, RPF Submandibular gl, 0.40
3c 79 1460 3669 160 (Homo + Spe) Anti-SS-A+ <6 Küttner’s tumor, IP, IN, RPF, LN Submandibular gl, 0.73
4 66 1090 2301 40 (Homo + Spe) 30.3 AIP, IN, Renal pseudotumor Kidney, 0.70
5c 73 592 3321 320 (Homo + Spe) <6 Sialadenitis, IP, IN, RPF, LN Submandibular gl, 0.43
6 74 389 2184 <40 <6 Retroorbital tumor Retroorbital tumor, 0.48
7 52 383 1748 <40 <6 Küttner’s tumor Submandibular gl, 0.57
8 70 724 1729 <40 <6 Küttner’s tumor, LN Submandibular gl, 0.40
9 46 675 1617 80 (Homo + Spe) 26.8 Mikulicz’s disease Lachrymal gl, 0.41
10 37 533 1741 <40 <6 Mikulicz’s disease Lachrymal gl, 0.50
11 76 458 1527 <40 <6 AIP, RPF Retroperitoneal tumor, 0.70
12 62 315 1809 40 (Spe) Anti-SS-A+ <6 AIP, RPF Pancreas, 0.43
13 79 1960 2953 40 (Homo + Spe) 65 Orbital tumor, Lung nodule, LN Orbital tumor, 0.59
14c 62 1460 2177 40 (Spe) 23.3 Sialadenitis, Laryngeal tumor, LN Parotid gl, 0.60 Cervical LN, 0.69
15 65 1050 1811 <40 19.8 Mikulicz’s disease, LN Submandibular LN, 0.80
16 25 1210 2181 <40 <6 Mikulicz’s disease, IP, IN, Renal pseudotumor, LN Minor salivary gl, 0.65
17 55 1510 3116 <40 72.2 Orbital tumor, RPF, Lung nodule, LN Cervical LN, 0.90
18 61 491 1466 80 (Spe + Granular) <6 Sialadenitis Submandibular gl, 0.48
19 78 1470 3762 80 (Homo + Spe) 35 AIP, RPF Vater’s ampulla, 0.48
  1. amg/dL in serum. bIU/mL. cShown in Fig. 1
  2. ANA: anti-nuclear antibody; gl: gland; Homo: homogeneous; IN: interstitial nephritis; IP: interstitial pneumonitis; LN: lymph node; RF: rheumatoid factor; RPF: retroperitoneal fibrosis; Spe: speckled