Screening for IgG4-type anti-nuclear antibodies in IgG4-related disease

Table 1 Clinical, serological, and histopathological features of IgG4-RD cases

Case	Age	IgG4^a	IgG^a	ANA Specific Abs	RF^b	Clinical manifestations	Biopsy source, IgG4⁺/IgG⁺ cell ratio
1	73	2890	3668	40 (Homo + Spe)	<6	Mikulicz’s disease, Prostatitis, LN	Prostate, 0.60
2	76	2210	3632	40 (Spe)	<6	Mikulicz’s disease, RPF	Submandibular gl, 0.40
3^c	79	1460	3669	160 (Homo + Spe) Anti-SS-A⁺	<6	Küttner’s tumor, IP, IN, RPF, LN	Submandibular gl, 0.73
4	66	1090	2301	40 (Homo + Spe)	30.3	AIP, IN, Renal pseudotumor	Kidney, 0.70
5^c	73	592	3321	320 (Homo + Spe)	<6	Sialadenitis, IP, IN, RPF, LN	Submandibular gl, 0.43
6	74	389	2184	<40	<6	Retroorbital tumor	Retroorbital tumor, 0.48
7	52	383	1748	<40	<6	Küttner’s tumor	Submandibular gl, 0.57
8	70	724	1729	<40	<6	Küttner’s tumor, LN	Submandibular gl, 0.40
9	46	675	1617	80 (Homo + Spe)	26.8	Mikulicz’s disease	Lachrymal gl, 0.41
10	37	533	1741	<40	<6	Mikulicz’s disease	Lachrymal gl, 0.50
11	76	458	1527	<40	<6	AIP, RPF	Retroperitoneal tumor, 0.70
12	62	315	1809	40 (Spe) Anti-SS-A⁺	<6	AIP, RPF	Pancreas, 0.43
13	79	1960	2953	40 (Homo + Spe)	65	Orbital tumor, Lung nodule, LN	Orbital tumor, 0.59
14^c	62	1460	2177	40 (Spe)	23.3	Sialadenitis, Laryngeal tumor, LN	Parotid gl, 0.60 Cervical LN, 0.69
15	65	1050	1811	<40	19.8	Mikulicz’s disease, LN	Submandibular LN, 0.80
16	25	1210	2181	<40	<6	Mikulicz’s disease, IP, IN, Renal pseudotumor, LN	Minor salivary gl, 0.65
17	55	1510	3116	<40	72.2	Orbital tumor, RPF, Lung nodule, LN	Cervical LN, 0.90
18	61	491	1466	80 (Spe + Granular)	<6	Sialadenitis	Submandibular gl, 0.48
19	78	1470	3762	80 (Homo + Spe)	35	AIP, RPF	Vater’s ampulla, 0.48

^amg/dL in serum. ^bIU/mL. ^cShown in Fig. 1
ANA: anti-nuclear antibody; gl: gland; Homo: homogeneous; IN: interstitial nephritis; IP: interstitial pneumonitis; LN: lymph node; RF: rheumatoid factor; RPF: retroperitoneal fibrosis; Spe: speckled

ISSN: 1471-2474