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Table 1 Mechanism of action of the products used in the study

From: The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study

Agent Brand Name Category Mechanism of action
Glutaraldehyde cross-linked albumin BioGlue Sealant Glutaraldehyde cross-links bovine albumin to cell proteins at wound site to form a tough scaffold [2].
Fibrin sealant (human) Evicel Sealant, hemostatic agent Thrombin and fibrinogen mixed at site of application; thrombin cleaves fibrinogen to clot-forming fibrin [2].
Butyl lactoyl cyanoacrylate Omnex Adhesive Liquid monomers that rapidly form polymers in the presence of water and thereby quickly glue surfaces together [2].
2-octyl cyanoacrylate Dermabond Adhesive Liquid monomers that rapidly form polymers in the presence of water and thereby quickly glue surfaces together [2].
Lysine-based dendritic hydrogel (PEG-LysNH2) Not available Sealant The cross-linked hydrogel forms an adhesive physical barrier on the wound’s surface [5] - hemostasis is not dependent on the clotting cascade.