The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study

Table 1 Mechanism of action of the products used in the study

Agent	Brand Name	Category	Mechanism of action
Glutaraldehyde cross-linked albumin	BioGlue	Sealant	Glutaraldehyde cross-links bovine albumin to cell proteins at wound site to form a tough scaffold [2].
Fibrin sealant (human)	Evicel	Sealant, hemostatic agent	Thrombin and fibrinogen mixed at site of application; thrombin cleaves fibrinogen to clot-forming fibrin [2].
Butyl lactoyl cyanoacrylate	Omnex	Adhesive	Liquid monomers that rapidly form polymers in the presence of water and thereby quickly glue surfaces together [2].
2-octyl cyanoacrylate	Dermabond	Adhesive	Liquid monomers that rapidly form polymers in the presence of water and thereby quickly glue surfaces together [2].
Lysine-based dendritic hydrogel (PEG-LysNH₂)	Not available	Sealant	The cross-linked hydrogel forms an adhesive physical barrier on the wound’s surface [5] - hemostasis is not dependent on the clotting cascade.

ISSN: 1471-2474