Table 1 Mechanism of action of the products used in the study

Glutaraldehyde cross-linked albumin

BioGlue

Sealant

Glutaraldehyde cross-links bovine albumin to cell proteins at wound site to form a tough scaffold [2].

Fibrin sealant (human)

Evicel

Sealant, hemostatic agent

Thrombin and fibrinogen mixed at site of application; thrombin cleaves fibrinogen to clot-forming fibrin [2].

Butyl lactoyl cyanoacrylate

Omnex

Adhesive

Liquid monomers that rapidly form polymers in the presence of water and thereby quickly glue surfaces together [2].

2-octyl cyanoacrylate

Dermabond

Adhesive

Liquid monomers that rapidly form polymers in the presence of water and thereby quickly glue surfaces together [2].

Lysine-based dendritic hydrogel (PEG-LysNH₂)

Not available

Sealant

The cross-linked hydrogel forms an adhesive physical barrier on the wound’s surface [5] - hemostasis is not dependent on the clotting cascade.