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Table 3 Evaluation of the experimental formulation during 12 months of intervention and 6 months of follow up in Lequesne Functional Index subscales

From: Effectiveness of intra-articular injections of sodium bicarbonate and calcium gluconate in the treatment of osteoarthritis of the knee: a randomized double-blind clinical trial

Lequesne subscales SBCG1 SBCG2
Score Change from baseline Score Change from baseline
Pain     
Baseline 5.4 (4.9, 5.9)a - 5.5 (5.1, 5.9) -
3 mo. 2.7 (2.1, 3.3)b −3.0 (−7.5, −3.8) 2.4 (1.8, 3.1) −2.9 (−3.6, −2.2)
8 mo. 2.0 (1.5, 2.6) −3.4 (−9.0, −4.1) 1.9 (1.3, 2.6) −3.5 (−4.3, −2.8)
12 mo. 1.4 (1.0, 1.9) −3.8 (−9.9, −4.6) 1.7 (1.1, 2.4) −3.9 (−4.6, −3.3)
18 mo. 1.3 (0.7, 1.9) −3.8 (−8.8, −4.7) 1.7 (1.0, 2.4) −4.0 (−4.7, −3.4)
Maximum walking distance    
Baseline 4.2 (3.4, 5.1) - 4.2 (3.6, 4.8) -
3 mo. 1.8 (0.9, 2.6) −2.9 (−6.4, −3.8) 2.2 (1.5, 2.9) −1.9 (−2.7, −1.2)
8 mo. 1.2 (0.5, 1.9) −3.2 (−6.8, −4.2) 1.4 (0.8, 1.9) −2.9 (−3.7, −2.1)
12 mo. 1.1 (0.4, 1.8) −3.2 (−6.7, −4.2) 1.2 (0.6, 1.8) −3.3 (−4.1, −2.5)
18 mo. 0.7 (−0.1, 1.4) −3.3 (−6.0, −4.4) 0.7 (0.2, 1.2) −3.7 (−4.4, −2.9)
Daily activities     
Baseline 8.0 (6.8, 9.2) - 7.5 (6.7, 8.3) -
3 mo. 4.0 (3.3, 4.8) −4.4 (−5.7, −6.0) 3.9 (3.3, 4.6) −3.7 (−4.6, −2.8)
8 mo. 3.5 (2.9, 4.2) −4.7 (−6.3, −6.2) 3.5 (2.9, 4.1) −4.2 (−5.2, −3.2)
12 mo. 2.8 (2.2, 3.4) −4.9 (−7.8, −6.2) 3.3 (2.6, 4.0) −4.7 (−5.8, −3.6)
18 mo. 2.8 (2.1, 3.6) −4.5 (−6.3, −6.0) 2.9 (2.2, 3.7) −5.0 (−6.4, −3.5)
Global score     
Baseline 17.6 (15.5, 19.8) - 17.2 (15.9, 18.5) -
3 mo. 8.5 (6.7, 10.2) −10.3 (−8.6, −12.7) 8.6 (7.0, 10.2) −8.6 (−10.2, −6.9)
8 mo. 6.8 (5.2, 8.3) −11.3 (−8.7, −13.9) 6.8 (5.3, 8.3) −10.6 (−12.5, −8.8)
12 mo. 5.3 (3.8, 6.8) −11.9 (−10.4, −14.2) 6.2 (4.6, 7.8) −11.9 (−13.8, −10.0)
18 mo. 4.8 (3.1, 6.4) −11.6 (−8.9, −14.4) 5.3 (3.7, 6.9) −12.7 (−14.8, −10.5)
  1. aAll values are means (95% confidence interval).
  2. bAll post-treatment measurements were significantly different from baseline value.
  3. There were no significant differences between treatments.