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Table 3 Evaluation of the experimental formulation during 12 months of intervention and 6 months of follow up in Lequesne Functional Index subscales

From: Effectiveness of intra-articular injections of sodium bicarbonate and calcium gluconate in the treatment of osteoarthritis of the knee: a randomized double-blind clinical trial

Lequesne subscales

SBCG1

SBCG2

Score

Change from baseline

Score

Change from baseline

Pain

    

Baseline

5.4 (4.9, 5.9)a

-

5.5 (5.1, 5.9)

-

3 mo.

2.7 (2.1, 3.3)b

−3.0 (−7.5, −3.8)

2.4 (1.8, 3.1)

−2.9 (−3.6, −2.2)

8 mo.

2.0 (1.5, 2.6)

−3.4 (−9.0, −4.1)

1.9 (1.3, 2.6)

−3.5 (−4.3, −2.8)

12 mo.

1.4 (1.0, 1.9)

−3.8 (−9.9, −4.6)

1.7 (1.1, 2.4)

−3.9 (−4.6, −3.3)

18 mo.

1.3 (0.7, 1.9)

−3.8 (−8.8, −4.7)

1.7 (1.0, 2.4)

−4.0 (−4.7, −3.4)

Maximum walking distance

   

Baseline

4.2 (3.4, 5.1)

-

4.2 (3.6, 4.8)

-

3 mo.

1.8 (0.9, 2.6)

−2.9 (−6.4, −3.8)

2.2 (1.5, 2.9)

−1.9 (−2.7, −1.2)

8 mo.

1.2 (0.5, 1.9)

−3.2 (−6.8, −4.2)

1.4 (0.8, 1.9)

−2.9 (−3.7, −2.1)

12 mo.

1.1 (0.4, 1.8)

−3.2 (−6.7, −4.2)

1.2 (0.6, 1.8)

−3.3 (−4.1, −2.5)

18 mo.

0.7 (−0.1, 1.4)

−3.3 (−6.0, −4.4)

0.7 (0.2, 1.2)

−3.7 (−4.4, −2.9)

Daily activities

    

Baseline

8.0 (6.8, 9.2)

-

7.5 (6.7, 8.3)

-

3 mo.

4.0 (3.3, 4.8)

−4.4 (−5.7, −6.0)

3.9 (3.3, 4.6)

−3.7 (−4.6, −2.8)

8 mo.

3.5 (2.9, 4.2)

−4.7 (−6.3, −6.2)

3.5 (2.9, 4.1)

−4.2 (−5.2, −3.2)

12 mo.

2.8 (2.2, 3.4)

−4.9 (−7.8, −6.2)

3.3 (2.6, 4.0)

−4.7 (−5.8, −3.6)

18 mo.

2.8 (2.1, 3.6)

−4.5 (−6.3, −6.0)

2.9 (2.2, 3.7)

−5.0 (−6.4, −3.5)

Global score

    

Baseline

17.6 (15.5, 19.8)

-

17.2 (15.9, 18.5)

-

3 mo.

8.5 (6.7, 10.2)

−10.3 (−8.6, −12.7)

8.6 (7.0, 10.2)

−8.6 (−10.2, −6.9)

8 mo.

6.8 (5.2, 8.3)

−11.3 (−8.7, −13.9)

6.8 (5.3, 8.3)

−10.6 (−12.5, −8.8)

12 mo.

5.3 (3.8, 6.8)

−11.9 (−10.4, −14.2)

6.2 (4.6, 7.8)

−11.9 (−13.8, −10.0)

18 mo.

4.8 (3.1, 6.4)

−11.6 (−8.9, −14.4)

5.3 (3.7, 6.9)

−12.7 (−14.8, −10.5)

  1. aAll values are means (95% confidence interval).
  2. bAll post-treatment measurements were significantly different from baseline value.
  3. There were no significant differences between treatments.