Table 2 Estimated treatment effects
| Â | Baseline to 1Â week pre-op | Baseline to 6Â weeks post-op | Baseline to 3Â months post-op | 3Â months to 12Â months post-op |
|---|---|---|---|---|
Primary endpoint | Â | Â | Â | Â |
Chair Stand Test° | −1.5 (−5.3, 2.2) | Not assessed | 2.0 (−1.8, 5.8) | Not assessed |
Secondary endpoints | Â | Â | Â | Â |
KOOS ADL function°° | 1.3 (−10.1, 12.8) | −2.0 (−13.3, 9.3) | −4.9 (−16.3, 6.5) | 3.6 (−8.5, 15.7) |
KOOS pain°° | −2.3 (−12.4, 7.9) | −6.4 (−16.5, 3.6) | −3.3 (−13.5, 6.8) | 2.3 (−8.5, 13.0) |
Additional outcomes | Â | Â | Â | Â |
Lower limb function | Â | Â | Â | Â |
KOOS symptoms°° | 2.2 (−7.4, 11.8) | 2.4 (−7.2, 11.9) | 4.6 (−5.0, 14.2) | 3.8 (−6.4, 14.0) |
KOOS sport and recreation°° | −5.1 (−24.5, 14.4) | 12.2 (−8.8, 33.2) | 1.0 (-19.9, 21.8) | −4.1 (−25.6, 17.5) |
KOOS quality of life°° | 5.5 (−7.2, 18.1) | 6.1 (−6.6, 18.7) | −5.9 (−18.5, 6.8) | 5.9 (−7.5, 19.3) |
Muscle strength (Newton)° |  | Not assessed |  | Not assessed |
  Knee extension op | 8.8 (−40.0, 57.8) |  | −3.5 (−52.7, 45.6) |  |
  Knee extension contra | 14.2 (−29.8, 58.2) |  | 35.4 (−8.9, 79.4) |  |
  Knee flexion op | 23.2 (−0.1, 46.5) |  | −12.7 (−36.2, 10.8) |  |
  Knee flexion contra | 2.0 (−20.8, 24.7) |  | −6.7 (−29.7, 16.2) |  |
Knee-bending/30s° | 3.8 (−0.5, 8.0) | Not assessed | −3.3 (−7.4, 0.8) | Not assessed |
ROM of the knee (degrees)° |  | Not assessed |  | Not assessed |
  Flexion op | 1.9 (−4.4, 8.2) |  | −3.9 (−10.2, 2.4) |  |
  Flexion contra | 0.1 (−3.4, 3.7) |  | −1.6 (−5.2, 1.9) |  |
  Extension op | 0.8 (−2.4, 4.0) |  | 1.4 (−1.8, 4.5) |  |
  Extension contra | 1.2 (−0.5, 2.8) |  | 1.4 (−0.2, 3.0) |  |
20 m walk test° | −0.6 (−2.0, 0.9) | Not assessed | −0.5 (−2.0, 1.0) | Not assessed |
Timed up and go° | 0.2 (−1.5, 2.0) | Not assessed | 1.6 (−0.1, 3.3) | Not assessed |
Physical activity | Â | Â | Â | Â |
METs 7 day (kcal/h/kg)° | 0.3 (−2.2, 2.7) | Not assessed | 0.3 (−2.3, 2.9) | Not assessed |
Steps (daily average)° | −687.2 (−2172, 798) | Not assessed | 165.7 (−1288, 1620) | Not assessed |
Adapted NHANES III METs° | 10.0 (−12.6, 32.7) | 1.6 (−20.9, 24.0) | 0.4 (−22.3, 23.0) | 2.6 (−21.3, 26.4) |
Health-related quality of life | Â | Â | Â | Â |
SF 36 Physical functioning°° | 7.1 (−5.3, 19.5) | 0.5 (−11.8, 12.7) | −6.6 (−8.5, 17.5) | 4.5 (−8.5, 17.5) |
  Role physical°° | −10.8 (−39.9, 18.3) | −5.2 (−34.2, 23.9) | −3.2 (−32.2, 25.9) | −1.1 (−31.7, 29.5) |
  Bodily pain°° | 4.9 (−7.2, 17.0) | 2.8 (−9.2, 14.9) | −3.4 (−15.5, 8.7) | 4.9 (−7.8, 17.7) |
  General health°° | 3.3 (−5.9, 12.4) | 3.4 (−5.7, 12.5) | −2.8 (−12.0, 6.3) | 2.5 (−7.2, 12.1) |
  Vitality°° | −2.3 (−13.9, 9.3) | −1.0 (−12.5, 10.5) | −8.3 (−20.0, 3.3) | 3.3 (−8.9, 15.5.) |
  Social functioning°° | 5.0 (−7.1, 17.2) | 2.4 (−9.7, 14.4) | −1.6 (-13.7, 10.5) | −0.7 (−13.4, 12.1) |
  Role emotional°° | −10.8 (−34.3, 12.7) | −11.1 (−34.5, 12.3) | −10.2 (−34.0, 13.5) | −9.3 (−34.2, 15.7) |
  Mental health°° | 2.6 (−6.6, 11.7) | −1.6 (−10.7, 7.5) | −3.0 (−12.2, 6.1) | 0.4 (−9.2, 10.0) |
EQ-5D Mobility°°° | 0.1 (−0.3, 0.4) | 0.0 (−0.3, 0.4) | −0.1 (−0.4, 0.2) | 0.1 (−0.3, 0.4) |
  Self-care°°° | −0.0 (−0.2, 2.2) | 0.1 (−0.2, 0.3) | 0.1 (−0.1, 0.3) | 0.0 (−0.2, 0.2) |
  Usual Activities°°° | −0.0 (−0.4, 0.4) | −0.1 (−0.5, 0.2) | 0.0 (−0.4, 0.4) | −0.1 (−0.4, 0.3) |
  Pain/discomfort°°° | −0.1 (−0.4, 0.2) | 0.1 (−0.3, 0.4) | −0.0 (−0.5, 0.3) | −0.1 (−0.4, 0.3) |
  Anxiety/Depression°°° | −0.1 (−0.3, 0.3) | 0.0 (−0.2, 0.2) | −0.0 (−0.3, 0.3) | 0.1 (−0.2, 0.3) |
EQ-VAS°° | 7.1 (−2.5, 16.7) | 2.1 (−7.4, 11.6) | 1.2 (−8.4, 10.8) | −0.1 (−10.2, 10.0) |