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Table 2 Effect of BIS076 on bone parameters after μCT analysis

From: Effects of BIS076 in a model of osteoarthritis induced by anterior cruciate ligament transection in ovariectomised rats

Metaphysis
  Sham Ovx Control T1 T2
BV/TV(%) 42.0 ± 11.5 12.6 ± 4.8++ 9.7 ± 2.1++ 15.1 ± 1.0 29.6 ± 7.7**
BS/TV(mm−1) 14.2 ± 0.4 4.9 ± 1.4++ 4.8 ± 0.8++ 6.7 ± 0.4 12.6 ± 0.6*
Tb.Th(μm) 102.7 ± 9.6 98.5 ± 6.6 94.3 ± 1.7 93.9 ± 1.6 96.6 ± 2.0
Tb.N(mm−1) 4.0 ± 0.3 1.2 ± 0.4++ 1.2 ± 0.2++ 1.7 ± 0.1 3.3 ± 0.1*
Tb.Pf(mm−1) 0.03 ± 0.02 12.1 ± 3.3++ 15.0 ± 0.8++ 10.6 ± 2.0 4.7 ± 2.2*
vBMD(mg/cm3) 413.0 ± 65.1 N.D. 89.8 ± 30.3++ 112.6 ± 23.5 154.1 ± 40.1*
Epiphysis
  Sham Ovx Control T1 T2
BV/TV(%) 40.3 ± 14.7 34.3 ± 1.7 32.3 ± 0.3 34.3 ± 1.6 33.8 ± 0.1
BS/TV(mm−1) 12.2 ± 0.9 10.7 ± 0.2 10.6 ± 0.6 10.7 ± 1.1 11.7 ± 0.4
Tb.Th(μm) 127.8 ± 1.7 115.2 ± 4.0 115.6 ± 2.9 120.3 ± 1.8 117.9 ± 3.9
Tb.N(mm−1) 3.4 ± 0.5 2.9 ± 0.1 2.9 ± 0.2 2.8 ± 0.3 3.1 ± 0.1
Tb.Pf(mm−1) 0.02 ± 0.02 5.0 ± 1.0++ 5.6 ± 0.6 3.8 ± 0.4 4.2 ± 1.2
vBMD(mg/cm3) 499.9 ± 107.4 434.6 ±15.3 431.0 ± 24.4 430.7 ± 66.1 467.6 ± 54.7
  1. Results are shown as mean ± SD (n = 3). ++P < 0.01 with respect to Sham; *P < 0.05, **P < 0.01 with respect to Control (ANOVA followed by Bonferroni’s test). N.D. not determined.
  2. Three-dimensional trabecular microarchitecture was analyzed at the metaphysis and epiphysis of the tibia.