Table 2 Effect of BIS076 on bone parameters after μCT analysis

BV/TV(%)

42.0 ± 11.5

12.6 ± 4.8⁺⁺

9.7 ± 2.1⁺⁺

15.1 ± 1.0

29.6 ± 7.7**

BS/TV(mm⁻¹)

14.2 ± 0.4

4.9 ± 1.4⁺⁺

4.8 ± 0.8⁺⁺

6.7 ± 0.4

12.6 ± 0.6*

Tb.Th(μm)

102.7 ± 9.6

98.5 ± 6.6

94.3 ± 1.7

93.9 ± 1.6

96.6 ± 2.0

Tb.N(mm⁻¹)

4.0 ± 0.3

1.2 ± 0.4⁺⁺

1.2 ± 0.2⁺⁺

1.7 ± 0.1

3.3 ± 0.1*

Tb.Pf(mm⁻¹)

0.03 ± 0.02

12.1 ± 3.3⁺⁺

15.0 ± 0.8⁺⁺

10.6 ± 2.0

4.7 ± 2.2*

vBMD(mg/cm³)

413.0 ± 65.1

N.D.

89.8 ± 30.3⁺⁺

112.6 ± 23.5

154.1 ± 40.1*

Sham

Ovx

Control

T1

T2

BV/TV(%)

40.3 ± 14.7

34.3 ± 1.7

32.3 ± 0.3

34.3 ± 1.6

33.8 ± 0.1

BS/TV(mm⁻¹)

12.2 ± 0.9

10.7 ± 0.2

10.6 ± 0.6

10.7 ± 1.1

11.7 ± 0.4

Tb.Th(μm)

127.8 ± 1.7

115.2 ± 4.0

115.6 ± 2.9

120.3 ± 1.8

117.9 ± 3.9

Tb.N(mm⁻¹)

3.4 ± 0.5

2.9 ± 0.1

2.9 ± 0.2

2.8 ± 0.3

3.1 ± 0.1

Tb.Pf(mm⁻¹)

0.02 ± 0.02

5.0 ± 1.0⁺⁺

5.6 ± 0.6

3.8 ± 0.4

4.2 ± 1.2

vBMD(mg/cm³)

499.9 ± 107.4

434.6 ±15.3

431.0 ± 24.4

430.7 ± 66.1

467.6 ± 54.7