Cartilage degradation and synovitis were scored in frontal sections of knee joints as indicated in materials and methods. Cartilage degradation was determined in accordance with the Osteoarthritis Research Society International (OARSI) histopathology grading and staging system . Synovitis was scored according to Krenn et al. . Results are expressed as mean ± SD (n = 5); ++P < 0.01 with respect to Sham; *P < 0.05 compared to Control (Kruskal-Wallis followed by Dunn's post-test).