A genome-wide association study of copy-number variation identifies putative loci associated with osteoarthritis in Koreans

Table 3 Summary of association result

Chr	Start	End	Length (bp)	Gene	OA type	CNV genotype frequency (%)^a		OR (95% CI)^b	Adjusted P-value^c
Chr	Start	End	Length (bp)	Gene	OA type	Cases (0/1/2)	Controls (0/1/2)	OR (95% CI)^b	Adjusted P-value^c
1	112490851	112509390	18539	Upstream of KCND3	Hand	23.0/52.9/24.0	13.1/52.5/34.5	0.41 (0.25 - 0.68)	5.8 × 10^-4
8	9535412	9536779	1367	Intron of TNKS	Hand, Knee	2.4/28.8/68.7	4.3/34.5/61.2	1.37 (1.02 - 1.85)	3.5 × 10^-2
9	71952096	71953157	1061	Intron of MAMDC2	Knee	-/7.2/92.8	-/3.0/97.0	0.36 (0.16 - 0.86)	1.9 × 10^-2
11	85981796	85983048	1252	Intron of ME3	Hand	6.9/33.3/59.8	11.1/40.5/48.4	1.70 (1.21 - 2.40)	2.4 × 10^-3
13	36971042	36976531	5489	Downstream of POSTN	Hand, Knee	2.4/31.3/66.3	1.5/22.5/76.0	0.64 (0.47- 0.87)	4.9 × 10^-3
17	47477132	47478158	1026	Intron of CA10	Hand	1.5/19.1/79.4	2.8/26.6/70.7	1.69 (1.14 - 2.55)	1.02 × 10^-2

^aDesignations for the CNV genotype are as indicated in the Methods. A dash indicates a zero-copy CNV region. OR^b and Adjusted P-value^c were adjusted by gender, age, and body mass index; OR: odds ratio, CI: Confidence interval.

ISSN: 1471-2474