|
Chr
|
Start
|
End
|
Length (bp)
|
Gene
|
OA type
|
CNV genotype frequency (%)a
|
OR (95% CI)b
|
Adjusted P-valuec
|
|---|
|
Cases (0/1/2)
|
Controls (0/1/2)
|
|---|
|
1
|
112490851
|
112509390
|
18539
|
Upstream of KCND3
|
Hand
|
23.0/52.9/24.0
|
13.1/52.5/34.5
|
0.41 (0.25 - 0.68)
|
5.8 × 10-4
|
|
8
|
9535412
|
9536779
|
1367
|
Intron of TNKS
|
Hand, Knee
|
2.4/28.8/68.7
|
4.3/34.5/61.2
|
1.37 (1.02 - 1.85)
|
3.5 × 10-2
|
|
9
|
71952096
|
71953157
|
1061
|
Intron of MAMDC2
|
Knee
|
-/7.2/92.8
|
-/3.0/97.0
|
0.36 (0.16 - 0.86)
|
1.9 × 10-2
|
|
11
|
85981796
|
85983048
|
1252
|
Intron of ME3
|
Hand
|
6.9/33.3/59.8
|
11.1/40.5/48.4
|
1.70 (1.21 - 2.40)
|
2.4 × 10-3
|
|
13
|
36971042
|
36976531
|
5489
|
Downstream of POSTN
|
Hand, Knee
|
2.4/31.3/66.3
|
1.5/22.5/76.0
|
0.64 (0.47- 0.87)
|
4.9 × 10-3
|
|
17
|
47477132
|
47478158
|
1026
|
Intron of CA10
|
Hand
|
1.5/19.1/79.4
|
2.8/26.6/70.7
|
1.69 (1.14 - 2.55)
|
1.02 × 10-2
|
- aDesignations for the CNV genotype are as indicated in the Methods. A dash indicates a zero-copy CNV region. ORb and Adjusted P-valuec were adjusted by gender, age, and body mass index; OR: odds ratio, CI: Confidence interval.
