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Table 5 Mean reduction on WOMAC A (Pain), B (Stiffness), and C (Function) scores (mm)*

From: Safety and performance of Hydros and Hydros-TA for knee osteoarthritis: a prospective, multicenter, randomized, double-blind feasibility trial

   Between Group Differences
  Mean reduction (Pain) from Baseline [LSMeans(SE)] Synvisc-One – Hydros Synvis-One – Hydros-TA
Time Points Synvisc-One n=32 Hydros n=32 Hydros-TA n=34 LSMeans p-value LSMeans p-value
Baseline 66.4 68.1 69.4 N/A N/A N/A N/A
2 weeks -28.5 (5.9) -23.3 (5.6) -35.6 (5.2) 5.2 0.40 -7.1 0.25
6 weeks -25.6 (5.9) -32.4 (5.6) -33.4 (5.2) -6.8 0.28 -7.8 0.21
13 weeks -29.0 (6.0) -33.9 (5.6) -33.3 (5.2) -4.9 0.43 -4.3 0.49
26 weeks -28.9 (6.0) -32.4 (5.6) -35.2 (5.3) -3.5 0.58 -6.3 0.33
Overall -28.0 (5.4) -30.5 (5.1) -34.4 (4.7) -2.5 0.64 -6.4 0.24
   Between Group Differences
  Mean reduction (Stiffness) from Baseline [LSMeans(SE)] Synvisc-One – Hydros Synvis-One – Hydros-TA
Time Points Synvisc-One n=32 Hydros n=32 Hydros-TA n=34 LSMeans p -value LSMeans p -value
Baseline 70.1 70.5 70.3 N/A N/A N/A N/A
2 weeks -25.9 (6.7) -18.4 (6.4) -33.7 (6.0) 7.5 0.29 -7.8 0.27
6 weeks -24.0 (6.7) -24.2 (6.4) -31.4 (6.0) -0.2 0.98 -7.4 0.30
13 weeks -25.9 (6.8) -26.4 (6.4) -27.4 (6.0) -0.5 0.94 -1.5 0.83
26 weeks -24.6 (6.9) -29.0 (6.5) -26.8 (6.0) -4.4 0.55 -2.2 0.77
Overall -25.1 (6.1) -24.5 (5.8) -29.8 (5.3) 0.6 0.92 -4.7 0.43
   Between Group Differences
  Mean reduction (Function) from Baseline [LSMeans(SE)] Synvisc-One – Hydros Synvis-One – Hydros-TA
Time Points Synvisc-One n=32 Hydros n=32 Hydros-TA n=34 LSMeans p -value LSMeans p -value
Baseline 63.5 66.2 65.1 N/A N/A N/A N/A
2 weeks -23.7 (6.0) -20.2 (5.8) -32.1 (5.3) 3.5 0.58 -8.4 0.18
6 weeks -23.5 (6.0) -29.2 (5.8) -29.0 (5.3) -5.7 0.37 -5.5 0.38
13 weeks -25.6 (6.1) -31.0 (5.8) -29.1 (5.3) -5.4 0.39 -3.5 0.58
26 weeks -24.5 (6.1) -29.0 (5.8) -29.5 (5.4) -4.5 0.49 -5.0 0.44
Overall -24.3 (5.6) -27.3 (5.4) -30.0 (4.9) -3.0 0.59 -5.6 0.31
  1. *For the intent-to-treat population in the Synvisc-One, Hydros, and Hydros TA groups, observed at landmark time points.
  2. Abbreviations: WOMAC = Western Ontario and McMaster Universities Osteoarthritis Index; LSMeans = Least Squares Means; SE = Standard Error.