Tissue volumes. (A) Femur fracture callus volume of control and rivaroxaban treated rats after 28 and 49 days was detected by micro CT-scan. Treated rats showed increase of callus volume compared to control group. 49 days after fracture callus was almost transformed to bone tissue. (B) Bone volume decreased from day 28 to day 49, but no significant differences could be seen between the groups. n = 6 (28 days); n = 3 (49 days).