3D imaging of the interfragmentary zone. (A) Tissue volumes of defined fracture zone of rats’ femur treated with rivaroxaban was determined by micro-CT analysis. During Fracture healing volume of bone tissue increased from 65.9 mm3 to 89.2 mm3. On the other hand callus volume decreased from 42.17 mm3 to 9.7 mm3. B + C The images show femurs of rivaroxaban treated rats 28 and 49 days after femur fracture. (B) 28-days-old femurs fracture reveals a fracture gap a sufficient callus (green). (C) 49 days after fracture the volume of callus tissue (green) had decreased and formatted to mineralised bone tissue.