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Table 1 Surgical options and effects for the treatment of patients with TIO

From: Surgical treatment of tumor-induced osteomalacia: a retrospective review of 40 cases with extremity tumors

No. Gender/age (year) Tumor location Primary surgical procedure Histopathology SP level/recovery day Secondary surgery/surgical procedure/SP level
1 F/42 soft tissue of right thigh Tumor resection MPNST Unnormalized No
2 F/41 soft tissue of left medial ankle Tumor resection GCTTS Normalized/8 days No
3 F/53 Bone tissue of right tibial plateau Curettage and bone allograft PMT Unnormalized Yes/Tumor resection and prosthesis reconstruction/Normalized
4 M/52 Bone tissue of medial condyle of right femur Curettage and bone allograft No tumor cells Unnormalized No
5 M/41 Soft tissue of right thigh Tumor resection PMT Normalized/6 days No
6 M/30 Bone and soft tissue of left distal femur Tumor resection and curettage with cement reconstruction Malignant PMT Unnormalized No
7 F/28 Soft tissue of left thigh Tumor resection PMT Normalized/7 days No
8 M/29 Soft tissue of right foot Tumor resection PMT Normalized/5 days No
9 M/57 Soft tissue of left leg Tumor resection PMT Normalized/6 days No
10 F/47 Soft tissue of left thigh Tumor resection PMTMCT Normalized/3 days No
11 M/57 Soft tissue of right thigh Tumor resection PMT Normalized/7 days No
12 M/27 Bone tissue of left greater trochanter Curettage and bone allograft PMT Unnormalized Yes/Curettage and bone allograft/Unnormalized
13 F/33 Bone and soft tissue of right leg Partial tumor resection PMT Unnormalized Yes/Amputation/normalized (malignant PMT)
14 F/43 Soft tissue of left leg Tumor resection and partial fibula resection PMT Normalized/3 days No
15 F/34 Bone and soft tissue of right leg Tumor resection and curettage with bone allograft Malignant PMT Unnormalized Yes/Amputation/Normalized
16 M/43 Soft tissue of left forearm Tumor resection and partial radius resection PMT Normalized/12 days No
17 F/49 Soft tissue of right thigh Tumor resection PMT Normalized/5 days No
18 M/54 Soft tissue of right foot Tumor resection PMT Normalized/7 days No
19* F/29 Soft tissue of right foot Tumor resection PMT Unnormalized No
20 M/39 Bone tissue of right femur head Tumor resection and THA PMT Normalized/6 days No
21 F/48 Soft tissue of left foot Tumor resection PMT Normalized/3 days No
22 M/66 Soft tissue of left thigh Tumor resection PMT Normalized/2 days No
23 M/50 Bone tissue of left tibial plateau Curettage and bone allograft PMT Unnormalized Yes/Tumor resection and prosthesis reconstruction/unnormalized
24 F/67 Soft tissue of left foot Tumor resection PMT Normalized/3 days No
25 M/47 Soft tissue of right hip Tumor resection PMT Normalized/6 days No
26 F/59 Bone tissue of medial condyle of right femur Curettage and bone allograft No tumor cells Normalized/7 days Yes/Tumor resection and prosthesis reconstruction/normalized (PMT)
27 M/37 Soft tissue of left foot Tumor resection PMT Normalized/3 days No
28 M/50 Soft tissue of right arm Tumor resection PMT Normalized/7 days No
29 M/29 Soft tissue of right leg Tumor resection PMT Normalized/5 days No
30 M/20 Bone tissue of right ulna Tumor resection and bone allograft PMT Unnormalized No
31 M/50 Bone tissue of right tibial plateau Curettage and bone allograft No tumor cells Unnormalized No
32 F/47 Bone tissue of right femur head Tumor resection and THA PMT Normalized/6 days No
33 M/32 Bone tissue of right greater trochanter Curettage and bone allograft PMT Normalized/8 days No
34 F/38 Bone tissue of right greater trochanter Curettage and bone allograft PMT Normalized/7 days No
35 M/39 Soft tissue of left thigh Tumor resection PMTMCT Normalized/4 days No
36 M/63 Bone tissue of right distal femur Curettage and bone allograft PMT Normalized/8 days No
37 M/46 Soft tissue of right foot Tumor resection PMTMCT Normalized/2 days No
38 M/31 Soft tissue of right wrist Tumor resection PMT Normalized/5 days No
39 F/57 Soft tissue of left thigh No tumor was found No tumor cells Unnormalized No
40 M/62 Soft tissue of right leg Tumor resection hemangioma Normalized/7 days No
  1. SP, serum phosphorus; MPNST, malignant peripheral nerve sheath tumor; GCTTS, giant cell tumor of tendon sheath; PMT, phosphaturic mesenchymal tumor; PMTMCT, PMT mixed connective tissue variant; THA, total hip arthroplasty.
  2. *This patient received tumor resection at the same region twice in other hospital and the tumor was not completely removed both times.
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