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Table 1 Surgical options and effects for the treatment of patients with TIO

From: Surgical treatment of tumor-induced osteomalacia: a retrospective review of 40 cases with extremity tumors

No.

Gender/age (year)

Tumor location

Primary surgical procedure

Histopathology

SP level/recovery day

Secondary surgery/surgical procedure/SP level

1

F/42

soft tissue of right thigh

Tumor resection

MPNST

Unnormalized

No

2

F/41

soft tissue of left medial ankle

Tumor resection

GCTTS

Normalized/8 days

No

3

F/53

Bone tissue of right tibial plateau

Curettage and bone allograft

PMT

Unnormalized

Yes/Tumor resection and prosthesis reconstruction/Normalized

4

M/52

Bone tissue of medial condyle of right femur

Curettage and bone allograft

No tumor cells

Unnormalized

No

5

M/41

Soft tissue of right thigh

Tumor resection

PMT

Normalized/6 days

No

6

M/30

Bone and soft tissue of left distal femur

Tumor resection and curettage with cement reconstruction

Malignant PMT

Unnormalized

No

7

F/28

Soft tissue of left thigh

Tumor resection

PMT

Normalized/7 days

No

8

M/29

Soft tissue of right foot

Tumor resection

PMT

Normalized/5 days

No

9

M/57

Soft tissue of left leg

Tumor resection

PMT

Normalized/6 days

No

10

F/47

Soft tissue of left thigh

Tumor resection

PMTMCT

Normalized/3 days

No

11

M/57

Soft tissue of right thigh

Tumor resection

PMT

Normalized/7 days

No

12

M/27

Bone tissue of left greater trochanter

Curettage and bone allograft

PMT

Unnormalized

Yes/Curettage and bone allograft/Unnormalized

13

F/33

Bone and soft tissue of right leg

Partial tumor resection

PMT

Unnormalized

Yes/Amputation/normalized (malignant PMT)

14

F/43

Soft tissue of left leg

Tumor resection and partial fibula resection

PMT

Normalized/3 days

No

15

F/34

Bone and soft tissue of right leg

Tumor resection and curettage with bone allograft

Malignant PMT

Unnormalized

Yes/Amputation/Normalized

16

M/43

Soft tissue of left forearm

Tumor resection and partial radius resection

PMT

Normalized/12 days

No

17

F/49

Soft tissue of right thigh

Tumor resection

PMT

Normalized/5 days

No

18

M/54

Soft tissue of right foot

Tumor resection

PMT

Normalized/7 days

No

19*

F/29

Soft tissue of right foot

Tumor resection

PMT

Unnormalized

No

20

M/39

Bone tissue of right femur head

Tumor resection and THA

PMT

Normalized/6 days

No

21

F/48

Soft tissue of left foot

Tumor resection

PMT

Normalized/3 days

No

22

M/66

Soft tissue of left thigh

Tumor resection

PMT

Normalized/2 days

No

23

M/50

Bone tissue of left tibial plateau

Curettage and bone allograft

PMT

Unnormalized

Yes/Tumor resection and prosthesis reconstruction/unnormalized

24

F/67

Soft tissue of left foot

Tumor resection

PMT

Normalized/3 days

No

25

M/47

Soft tissue of right hip

Tumor resection

PMT

Normalized/6 days

No

26

F/59

Bone tissue of medial condyle of right femur

Curettage and bone allograft

No tumor cells

Normalized/7 days

Yes/Tumor resection and prosthesis reconstruction/normalized (PMT)

27

M/37

Soft tissue of left foot

Tumor resection

PMT

Normalized/3 days

No

28

M/50

Soft tissue of right arm

Tumor resection

PMT

Normalized/7 days

No

29

M/29

Soft tissue of right leg

Tumor resection

PMT

Normalized/5 days

No

30

M/20

Bone tissue of right ulna

Tumor resection and bone allograft

PMT

Unnormalized

No

31

M/50

Bone tissue of right tibial plateau

Curettage and bone allograft

No tumor cells

Unnormalized

No

32

F/47

Bone tissue of right femur head

Tumor resection and THA

PMT

Normalized/6 days

No

33

M/32

Bone tissue of right greater trochanter

Curettage and bone allograft

PMT

Normalized/8 days

No

34

F/38

Bone tissue of right greater trochanter

Curettage and bone allograft

PMT

Normalized/7 days

No

35

M/39

Soft tissue of left thigh

Tumor resection

PMTMCT

Normalized/4 days

No

36

M/63

Bone tissue of right distal femur

Curettage and bone allograft

PMT

Normalized/8 days

No

37

M/46

Soft tissue of right foot

Tumor resection

PMTMCT

Normalized/2 days

No

38

M/31

Soft tissue of right wrist

Tumor resection

PMT

Normalized/5 days

No

39

F/57

Soft tissue of left thigh

No tumor was found

No tumor cells

Unnormalized

No

40

M/62

Soft tissue of right leg

Tumor resection

hemangioma

Normalized/7 days

No

  1. SP, serum phosphorus; MPNST, malignant peripheral nerve sheath tumor; GCTTS, giant cell tumor of tendon sheath; PMT, phosphaturic mesenchymal tumor; PMTMCT, PMT mixed connective tissue variant; THA, total hip arthroplasty.
  2. *This patient received tumor resection at the same region twice in other hospital and the tumor was not completely removed both times.