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Figure 2 | BMC Musculoskeletal Disorders

Figure 2

From: Alterations in the vimentin cytoskeleton in response to single impact load in an in vitro model of cartilage damage in the rat

Figure 2

2a Histological section of cartilage obtained from the distal femur of a rat at 23 weeks of age. This is a control section i.e. has not received single impact load and it is has not been cultured i.e. represents a control section, T = 0. Stained with toluidine blue. There is no damage to the cartilage; the articular surface is smooth and flat. There are no micro-fractures or fragments and there is no loss of proteoglycan. Scale bar = 10 μm. 2b Histological section of cartilage obtained from the distal femur of a rat at 23 weeks of age. This cartilage has been impacted with a single impact load of 200 g from 8 cm. T = 0. Stained with toluidine blue. There is marked surface damage to the cartilage including lamination. Scale bar = 10 μm. 2c Histological section of cartilage obtained from the distal femur of a rat at 23 weeks of age. This cartilage has been impacted with a single impact load of 200 g from 8 cm. T = 0. Stained with toluidine blue. There is marked surface damage to the cartilage including the formation of a fragment discreet from the parent cartilage. Scale bar = 10 μm. 2d Histological section of cartilage obtained from the distal femur of a rat at 23 weeks of age. This cartilage has been impacted with a single impact load of 200 g from 8 cm. This cartilage has been cultured for 48 hours i.e. T = 48 h. Stained with toluidine blue. There is a fissure at the articular surface and marked proteoglycan loss. Scale bar = 10 μm

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