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Table 5 Change in bone mineral density

From: Choline-stabilized orthosilicic acid supplementation as an adjunct to Calcium/Vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial

  Placebo (n = 20) ch-OSA
   3 mg Si (n = 18) 6 mg Si (n = 19) 12 mg Si (n = 24)
Spine total 0.58 ± 2 0.08 ± 3 0.24 ± 2 0.11 ± 3
Femur total -0.54 ± 2 0.07 ± 3 0.44 ± 3 0.04 ± 3
Femur neck -1.22 ± 3 -1.58 ± 3 0.78 ± 3a,b -0.84 ± 2c
  1. Relative % change in bone mineral density compared to baseline (mean ± SD), after 12 months supplementation with placebo (Ca/vit D) and three different ch-OSA doses (Si + Ca/vit D; Si: 3, 6, 12 mg/day), in a subgroup of patients with documented osteopenia at the femur. a: p < 0.05 versus placebo, b: p < 0.05 (t-test) versus 3 mg Si and c: p < 0.05 versus 6 mg Si (t-test).