| Â | Placebo (n = 20) | ch-OSA |
|---|
| Â | Â | 3 mg Si (n = 18) | 6 mg Si (n = 19) | 12 mg Si (n = 24) |
|---|
Spine total
| 0.58 ± 2 | 0.08 ± 3 | 0.24 ± 2 | 0.11 ± 3 |
Femur total
| -0.54 ± 2 | 0.07 ± 3 | 0.44 ± 3 | 0.04 ± 3 |
Femur neck
| -1.22 ± 3 | -1.58 ± 3 | 0.78 ± 3a,b
| -0.84 ± 2c
|
- Relative % change in bone mineral density compared to baseline (mean ± SD), after 12 months supplementation with placebo (Ca/vit D) and three different ch-OSA doses (Si + Ca/vit D; Si: 3, 6, 12 mg/day), in a subgroup of patients with documented osteopenia at the femur. a: p < 0.05 versus placebo, b: p < 0.05 (t-test) versus 3 mg Si and c: p < 0.05 versus 6 mg Si (t-test).
