Table 2 Efficacy of anti-TNFα drugs on ACR20, ACR50 and ACR70 responses

Lipsky et al. (19) Infliximab+MTX vs. MTX 12 months

3 mg/Kg 8 wk +MTX*

86

22/86

7/86

36/86

18/86

9/86

3 mg/Kg 4 wk +MTX

86

43/86

25/86

9/86

41/86

29/86

31/86

10 mg/Kg 8 wk +MTX

87

43/86

27/87

15/87

51/87

34/87

22/87

10 mg/Kg 4 wk +MTX

81

45/87

21/81

9/81

48/81

31/81

15/81

Total Infliximab

340

47/81

95/340

40/340

176/340

112/340

77/340

MTX

88

178/340

4/88

0/88

15/88

7/88

2/88

Total

428

18/88

St. Clair et al. (20) Infliximab+MTX vs. MTX 12 months

3 mg/Kg 8 wk +MTX*

373

NA

NA

231/373

171/373

123/373

6 mg/Kg 8 wk +MTX

378

249/378

189/378

140/378

Total Infliximab

751

NA

480/751

360/751

263/751

MTX

298

161/298

95/298

62/298

Total

1049

Quinn et al. (22) Infliximab+MTX vs. MTX 12 months

3 mg/Kg 8 wk +MTX*

10

8/10

8/10

7/10

MTX

10

NA

NA

NA

6/10

4/10

3/10

Total

20

Westhovens et al. (23) Infliximab+MTX vs. MTX 6 months

3 mg/Kg 8 wk +MTX*

360

110/360

48/360

10 mg/Kg 8 wk +MTX

361

199/360

119/361

54/341

Total Infliximab

721

205/361

229/721

102/721

MTX

363

404/721

33/363

16/363

Total

1084

87/363

oreland et al. (24) Etanercept vs. placebo 6 months

25 mg 2 twice weekly *

78

31/78

11/78

10 mg 2 twice weekly

76

46/78

18/76

7/76

Total Etanercept

154

37/76

49/154

18/154

Placebo

80

83/154

4/80

1/80

Total

234

9/80

Weinblatt et al. (25) Etanercept+MTX vs. MTX 6 months

25 mg 2 +MTX *

59

42/59

23/59

9/59

MTX

30

8/30

1/30

0/30

Total

89

Bathon et al. (26) ** Etanercept vs. MTX 12 months

25 mg 2 twice weekly *

207

147/207

NA

NA

149/207

101/207

52/207

10 mg 2 twice weekly

208

NA

NA

NA

NA

NA

NA

Total Etanercept

415

56/217

NA

NA

141/217

93/217

47/217

MTX

217

Total

632

van der Heijde et al. (28) (TEMPO) Etanercept+MTX vs. etanercept vs MTX 24 months

25 mg 2 twice weekly +MTX *

231

NA

NA

NA

196/231

159/231

99/231

199/231

164/231

113/231

25 mg 2 twice weekly*

223

169/223

107/223

54/223

167/223

120/223

60/223

Total Etanercept

454

365/454

266/454

153/454

386/454

284/454

173/454

MTX

228

171/228

98/228

43/228

162/228

96/228

4/228

Total

682

Weinblatt et al. (29) ARMADA) dalimumab+MTX vs. MTX 6 months

40 mg/2 s+MTX*

67

45/67

37/67

18/67

20 mg/2 s+MTX

69

33/69

22/69

7/69

80 mg/2 s+MTX

73

48/73

31/73

14/73

Total Adalimumab

209

126/209

90/209

39/209

MTX

62

9/62

5/62

3/62

Total

271

van de Putte et al. (30) Adalimumab vs. Placebo 6 months

40 mg/2 wk *

113

25/113

14/113

20 mg/2 wk

106

52/113

20/106

9/106

20 mg/wk

112

38/106

23/112

11/112

40 mg/wk

103

44/112

36/103

19/103

Total Adalimumab

434

55/103

104/434

53/434

Placebo

110

189/434

9/110

2/110

Total

544

21/110

Furst et al. (31) (STAR) Adalimumab+DAMAR D vs. DAMARD 6 months

40 mg/2 wk *

318

93/318

47/318

DMARD

318

169/318

35/318

10/318

Total

636

111/318

Keystone et al. (32) Adalimumab+MTX vs. MTX 12 months

40 mg/2 wk +MTX*

207

131/207

80/207

43/207

122/207

86/207

48/207

20 mg/wk +MTX

212

129/212

87/212

36/212

116/212

80/212

44/212

Total Adalimumab

419

260/419

167/419

79/419

238/419

166/419

92/419

MTX

200

59/200

19/200

5/200

48/200

19/200

9/200

Total

619

Breedveld et al. (33) (PREMIER) Adalimumab+MTX vs. adalimumab vs MTX 24 months

40 mg/2 wk+MTX*

268

NA

NA

NA

196/268

166/268

123/268

185/268

158/268

126/268

40 mg/2 wk *

274

148/274

112/274

71/274

134/274

101/274

77/274

Total Adalimumab

542

344/542

278/542

194/542

319/542

259/542

203/542

MTX

257

162/257

118/257

72/257

144/257

111/257

72/257