Figure 4From: Tumor necrosis factor alpha drugs in rheumatoid arthritis: systematic review and metaanalysis of efficacy and safety Efficacy of anti-TNFα drugs depending on an insufficient response to MTX prior to trial commencement. Effect refers to risk of obtaining the corresponding response with anti-TNFα drug relative to control treatment. 'Lower' and 'Upper' represent the 95% confidence interval limits for the efficacy estimate. Random-effect models.Back to article page