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Table 4 MDC, MCS and ROC values for neck pain and referred pain only in patients with referred pain at baseline, and differences depending on baseline pain severity and chronicity

From: Minimum detectable and minimal clinically important changes for pain in patients with nonspecific neck pain

Measurement of change

Value (all 487 patients with referred pain at baseline)

Baseline pain severity (PI-NRS)

Chronicity

  

Lowest tertile* (< 6 points)

Highest tertile* (≥ 8 points)

Subacute (<90 days)

Chronic (≥ 90 days)

Neck pain (PI-NRS)

     

MDC; Value (95% CI)**

4.2 (3.4–5.5)

    

   n

34

11

19

6

28

MCS (SD)

4.1 (2.3)

2.5 (1.2)

4.8 (2.4)

4.1 (2.4)

4.1 (2.3)

   n

306

61

167

120

182

ROC curve

     

   Area (IC 95%)

0.91 (0.86–0.97)

0.92 (0.80–1.00)

0.93 (0.88–0.99)

1.00 (0.99–1.00)

0.89 (0.82–0.96)

   Sensitivity

0.93

0.88

0.87

0.99

0.93

   Specificity

0.81

0.91

0.86

1.00

0.77

   ROC

1.5

1.5

2.5

0.5

1.5

   N

485

114

249

202

279

Pain referred to the arm (PI-NRS)

     

MDC; Value (95% CI)**

6.2 (5.0–8.2)

    

   n

35

11

19

7

30

MCS (SD)

4.1 (2.7)

2.4 (1.7)

5.3 (3.0)

3.7 (3.4)

3.6 (3.2)

   n

304

96

127

127

193

ROC curve

     

   Area (IC 95%)

0.81 (0.73–0.89)

0.80 (0.65–0.95)

0.86 (0.76–0.96)

0.89 (0.78–1.00)

0.76 (0.68–0.85)

   Sensitivity

0.87

0.79

0.87

0.90

0.81

   Specificity

0.71

0.82

0.77

0.86

0.71

   ROC

1.5

1.5

2.5

0.5

1.5

   N

479

159

201

214

293

  1. PI-NRS: Pain intensity numerical rating scale
  2. MDC: Minimal detectable change. MCS: Mean change score. ROC: Optimal cutoff point on the ROC curve.
  3. *: Lowest and highest tertiles do not represent the same number of patients because of repeated scores for pain severity.
  4. 1.2.1:** The low number of patients denying any change in this sample made it impossible to reliably estimate the potential effect of baseline pain severity and chronicity status on MDC values.