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Table 2 Quality of the quality evidence, definitions and underlying methodology

From: Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system

Grade Definition Underlying Methodology
High Further research is very unlikely to change our confidence in the estimate of effect RCT or meta-analysis
Moderate Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate Downgraded RCTs or upgraded observational studies
Low Further research is very likely to have an important impact on our confidence in the estimate of effect an its likely to change the estimate Well-done observational studies with control groups
Very low Any estimate of effect is very uncertain Others (e.g., case reports or case series)