Bone resorption. Upper panel: Urinary CTXI during 2 years of therapy in the groups receiving 2.5 mg, 1.25 mg of tibolone, or placebo. Values shown are geometric mean ± 1 SEM. B. Lower panel: Mean relative change from baseline in urinary CTXI during 2 years of therapy with 1.25 and 2.5 mg of tibolone. Values shown are placebo-corrected time-averaged mean change during the treatment period and given as mean ± 1 SEM. The level of significance denotes difference from the placebo group: *** p < 0.001. Modified with permission from .