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Table 2 EASE analysis of genes with significant fold differences greater than 2

From: Differential gene expression associated with postnatal equine articular cartilage maturation

GO System Gene Category List Hits List Total Population Hits Population Total EASE Score Official Gene Symbols
Cellular Component Extracellular 19 37 258 2760 3.27E-10 CHAD, CILP, CLU, COL2A1, COL9A1, COMP, CP, FMOD, FN1, FRZB, GAS6, LOXL2, NID2, PRELP, SERPINA5, SULF1, THSD1, TIMP2, TNC
Cellular Component Extracellular Matrix 11 37 101 2760 3.17E-07 CHAD, COL2A1, COL9A1, COMP, FMOD, FN1, NID2, PRELP, THSD1, TIMP2, TNC
Molecular Function Extracellular Matrix Structural Constituent 6 40 35 2830 9.16E-05 CHAD, COL2A1, COL9A1, COMP, FN1, PRELP
Biological Process Skeletal Development 6 38 55 2780 0.00068 ANKH, COL2A1, COMP, DLX5, FRZB, PRELP
Biological Process Cell Adhesion 8 38 151 2780 0.00315 COL2A1, COL9A1, COMP, FN1, LOXL2, NID2, THSD1, TNC
Cellular Component Extracellular Space 5 37 71 2760 0.01273 CP, FN1, LOXL2, SERPINA5, SULF1
Biological Process Development 11 38 410 2780 0.03681 ANKH, BOC, CLU, COL2A1, COL9A1, COMP, DLX5, FRZB, LOXL2, PRELP, TGFBR3
Biological Process Heparan Sulfate Proteoglycan Metabolism 2 38 5 2780 0.06484 HS3ST3A1, SULF1
Biological Process Acute-phase Response 2 38 6 2780 0.07731 FN1, SERPINA5
Molecular Function Scavenger Receptor Activity 2 40 6 2830 0.07996 KIAA1822, LOXL2
Biological Process Organogenesis 7 38 231 2780 0.08131 ANKH, COL2A1, COL9A1, FRZB, PRELP
Molecular Function Transmembrane Receptor Activity 5 40 122 2830 0.08470 FRZB, KIAA1822, LOXL2, PDGFRL, TNC
Molecular Function Receptor Activity 7 40 233 2830 0.09626 FRZB, KIAA1822, LOXL2, NR1D2, PDGFRL, TGFBR3, TNC
  1. "GO System" represents the major ontological system (i.e., cellular component, biological process, or molecular function). "Gene category" is a descriptive term shared by a group of genes. "List hits" are the numbers of differentially abundant transcripts that belong to the gene category. "List total" is the number of differentially expressed genes within the corresponding cellular component, biological process, or molecular function system. "Population hits" represent the total number of genes found on the microarray possessing that specific gene category annotation (e.g., extracellular, skeletal development, etc.). "Population Total" represents the total number of genes found on the microarray possessing that GO system annotation. "EASE score" is a measure of overrepresentation that scales the results of a statistical analysis (Fisher's exact test) by biasing against categories supported by few genes. Gene symbols of differentially expressed probe sets represented for each gene category are given in the last column.