Skip to main content

Table 2 EASE analysis of genes with significant fold differences greater than 2

From: Differential gene expression associated with postnatal equine articular cartilage maturation

GO System

Gene Category

List Hits

List Total

Population Hits

Population Total

EASE Score

Official Gene Symbols

Cellular Component

Extracellular

19

37

258

2760

3.27E-10

CHAD, CILP, CLU, COL2A1, COL9A1, COMP, CP, FMOD, FN1, FRZB, GAS6, LOXL2, NID2, PRELP, SERPINA5, SULF1, THSD1, TIMP2, TNC

Cellular Component

Extracellular Matrix

11

37

101

2760

3.17E-07

CHAD, COL2A1, COL9A1, COMP, FMOD, FN1, NID2, PRELP, THSD1, TIMP2, TNC

Molecular Function

Extracellular Matrix Structural Constituent

6

40

35

2830

9.16E-05

CHAD, COL2A1, COL9A1, COMP, FN1, PRELP

Biological Process

Skeletal Development

6

38

55

2780

0.00068

ANKH, COL2A1, COMP, DLX5, FRZB, PRELP

Biological Process

Cell Adhesion

8

38

151

2780

0.00315

COL2A1, COL9A1, COMP, FN1, LOXL2, NID2, THSD1, TNC

Cellular Component

Extracellular Space

5

37

71

2760

0.01273

CP, FN1, LOXL2, SERPINA5, SULF1

Biological Process

Development

11

38

410

2780

0.03681

ANKH, BOC, CLU, COL2A1, COL9A1, COMP, DLX5, FRZB, LOXL2, PRELP, TGFBR3

Biological Process

Heparan Sulfate Proteoglycan Metabolism

2

38

5

2780

0.06484

HS3ST3A1, SULF1

Biological Process

Acute-phase Response

2

38

6

2780

0.07731

FN1, SERPINA5

Molecular Function

Scavenger Receptor Activity

2

40

6

2830

0.07996

KIAA1822, LOXL2

Biological Process

Organogenesis

7

38

231

2780

0.08131

ANKH, COL2A1, COL9A1, FRZB, PRELP

Molecular Function

Transmembrane Receptor Activity

5

40

122

2830

0.08470

FRZB, KIAA1822, LOXL2, PDGFRL, TNC

Molecular Function

Receptor Activity

7

40

233

2830

0.09626

FRZB, KIAA1822, LOXL2, NR1D2, PDGFRL, TGFBR3, TNC

  1. "GO System" represents the major ontological system (i.e., cellular component, biological process, or molecular function). "Gene category" is a descriptive term shared by a group of genes. "List hits" are the numbers of differentially abundant transcripts that belong to the gene category. "List total" is the number of differentially expressed genes within the corresponding cellular component, biological process, or molecular function system. "Population hits" represent the total number of genes found on the microarray possessing that specific gene category annotation (e.g., extracellular, skeletal development, etc.). "Population Total" represents the total number of genes found on the microarray possessing that GO system annotation. "EASE score" is a measure of overrepresentation that scales the results of a statistical analysis (Fisher's exact test) by biasing against categories supported by few genes. Gene symbols of differentially expressed probe sets represented for each gene category are given in the last column.