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Figure 6 | BMC Musculoskeletal Disorders

Figure 6

From: Dystrophin deficiency in canine X-linked muscular dystrophy in Japan (CXMDJ) alters myosin heavy chain expression profiles in the diaphragm more markedly than in the tibialis cranialis muscle

Figure 6

Proportions of fiber types in skeletal muscles of a normal or a CXMD J dog at various ages. The numbers of fast (black), hybrid (gray), and slow MHC myofibers (white) among populations of myofibers without developmental MHC (A, B) and with developmental MHC (C) were counted in TC muscle and diaphragm of a normal (A) or an affected dog (B, C) at adolescent (2 or 4 months old) or adult stages (10 or 11 months old). The numbers under the ages show total fibers examined. MHC expression between two groups (normal, dMHC (-) vs affected, dMHC (-); affected, dMHC (-) vs affected, dMHC (+)), between muscles (TC muscle vs diaphragm), or among ages (2, 4, and 10 or 11 months) was analyzed by Yates's chi-square test. Significant differences (p < 0.05) were detected in all tests, except for no significant differences between 4 and 10 months old in normal TC muscles or diaphragms. Note that slow MHC fibers were consistently larger than other fibers, in populations of muscle fibers without developmental MHC of affected diaphragms. In populations of muscle fibers co-expressing developmental MHC and other MHC isoform(s), slow MHC and hybrid fibers were increased markedly in the affected diaphragm at 4 and 11 months old, unlike TC muscles.

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