Figure 2

The size distribution of myofibers expressing fast and/or slow type MHCs in skeletal muscles of a normal (10 months old) or a CXMD _J dog (11 months old). On the basis of expression of fast and slow type MHCs, all fibers within an area of TC muscle or diaphragm of a normal (A) or an affected dog (B, C) were classified into three types of MHC-positive fiber. Furthermore, fast (white), hybrid (gray), or slow MHC myofibers (black) were analyzed among populations of muscle fibers with non-expression of developmental MHC (A, B) or with expression of developmental MHC (C) in terms of fiber numbers (see Table 1) and fiber sizes (A-C). Note that larger sizes of slow MHC fibers were noticeable in populations of muscle fibers expressing fast and/or slow MHC(s) but not developmental MHC of affected muscles (B).