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Table 3 Summary of calculations fort individual coxibs, and all coxibs combined

From: Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk

 

Annual event rate per 100

Annual event rate per 1000

Absolute risk frequency per year

 

Annual event rate per 100

Annual event rate per 1000

Absolute risk frequency per year

All coxib vs All NSAID

Lumiracoxib vs NSAID

PUB

   

PUB

   

NSAID

1.36

13.6

74

NSAID

1.21

12.1

83

All coxib

0.56

5.6

179

Lumiracoxib

0.46

4.6

217

Difference

 

8.0

125

Difference

 

7.5

133

APTC

   

APTC

   

NSAID

0.89

8.9

112

NSAID

0.82

8.2

122

All coxib

0.97

9.7

103

Lumiracoxib

0.92

9.2

109

Difference

 

-0.8

-1250

Difference

 

-1.0

-1000

Celecoxib vs NSAID

Valdecoxib vs NSAID

PUB

   

PUB

   

NSAID

2.09

20.9

48

NSAID

1.95

19.5

51

Celecoxib

0.93

9.3

108

Valdecoxib

0.68

6.8

147

Difference

 

11.6

86

Difference

 

12.7

79

APTC

   

APTC

   

NSAID

1.20

12.0

83

NSAID

1.97

19.7

51

Celecoxib

1.00

10

100

Valdecoxib

1.27

12.7

79

Difference

 

2.0

500

Difference

 

7.0

143

Rofecoxib vs NSAID

Etoricoxib vs NSAID

PUB

   

PUB

   

NSAID

0.90

9.0

111

NSAID

1.03

10.3

97

Rofecoxib

0.33

3.3

303

Etoricoxib

0.47

4.7

213

Difference

 

5.7

175

Difference

 

5.6

179

APTC

   

APTC

   

NSAID

0.87

8.7

115

NSAID

0.80

8.0

125

Rofecoxib

1.19

11.9

84

Etoricoxib

0.91

9.1

110

Difference

 

-3.2

-313

Difference

 

-1.1

-909

  1. PUB – perforations, ulcers, bleeds; APTC – Antiplatelet Triallists Collaboration outcome of fatal and nonfatal heart attack or stroke, and cardiovascular death. In these calculations, the annualised event rates have been converted for simplicity to event rates per 1000 patients, and absolute event frequency per year calculated from that. Differences between NSAID and coxibs were calculated, and the absolute risk difference frequency calculated. This is equivalent to a number needed to prevent one event if positive, and number needed to harm if negative, for one year of treatment of coxib rather than an NSAID