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Figure 2 | BMC Musculoskeletal Disorders

Figure 2

From: Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ)

Figure 2

Immunohistochemical analysis of CD11b or MHCd expression, and film in situ zymography in the presence and absence of an MMP inhibitor (FIZ-PT) in the skeletal muscle of CXMD J dogs. A-D: serial sections of CXMDJ muscle characterized by extensive necrosis and an invading inflammatory infiltrate; E-H: serial sections of groups of regenerating fibers in CXMDJ muscle. A and B: H&E staining; B and F: immunohistochemical analysis of CD11b; C and G: FIZ-GN; D and H: FIZ in the presence of an MMP inhibitor (1,10-phenanthrolone) (FIZ-PT). Gelatinolytic activity co-localized with CD11b and MHCd, immunoreactivity and was attenuated by adding 1,10-phenanthrolone to the FIZ assay system. Bars, 50 μm.

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