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Table 5 Characteristics of included trials of Low Level Laser Therapy for pain relief in patients with knee osteoarthritis

From: Short-term efficacy of physical interventions in osteoarthritic knee pain. A systematic review and meta-analysis of randomised placebo-controlled trials

First author, publication year Intervention type, treatment period No of patients on active therapy (n = 187) Method quality Mean baseline pain (mm VAS) Best mean difference (95% CI) of change over placebo (mm VAS) Outcome assessment timepoints (weeks, best time point used in bold)
Bulow-94** 25 mW, 830 nm, 2.25 J to 10 points 3 times/week, 9 total sessions 15 2 82.0 8.0 (-10.8 to 26.8) 3, 6
Gøtte-95 12 mW, 904 nm, 12 J in 4 points, 3 times/week 12 total sessions 20 3 69.0 25.0 (9.4 to 40.7) 4
Gur-03 10 mW, 904 nm, 2 or 3 J applied to 2 points, 2–3 times week/10 total sessions 60 4 73.9 25.0 (18.9 to 31.1) 4, 8, 12
Hegedu-06 50 mW, 830 nm, 6 J applied to 8 points, 2 times/week, total 8 sessions 14 3 57.5 25.1 (2.5 to 47.7) 4, 6, 12
Nivbrant-92 4 mW 904 nm, 0.7 J in 3 points, 3 times/week, 6 total sessions 15 4 67 19 (2.4 to 35.6) 2, 6
Stelian-92 2.7 mW and 25 mW 904 + 820 nm, 1.3 J and 11.1 J in two points 10 times/week, 20 total sessions 18 4 72.0 41 (25.4 to 56.6) 2, 10
Tascioglu-05** 50 mW 830 nm, 1.5 or 3 J in 5 points, 5 times/week, 10 total sessions 20 3 66.5 -0.9 (-11.8 to 10) 3
Yurtkuran-06 ** 4 mW, 904 nm, 0.48 J in one acupoint (Sp9), 5 times/week, 10 total sessions 25 5 - -0.7 (-18.6 to 17.2) 2, 12
Best within 4 weeks, all trials††   187    17.7 † (8.1 to 27.3)  
Best within 4 weeks, optimal   142    24.2 (17.3 to 31.1)  
6–8 weeks   104    15.5 (9.9 to 20.9)  
12 weeks   99    12.3 (6.7 to 17.9)  
Total   187 3.5* 70.3†   3*
  1. *Mean † Weighted mean †† Random effects model used for calculation ** Non-optimal dose