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Table 1 Correspondence of the score (0–3) for the histological findings for each parameter considered during semiquantitative histopathological evaluation.

From: Preliminary study on the effect of parenteral naloxone, alone and in association with calcium gluconate, on bone healing in an ovine "drill hole" model system

Grade Surrounding Cavities Macrophages Mesenchymal Cells Osteoblasts Osteoclasts Fibrous Tissue Cartilage
0 None None None None None None
1 Occupying less than 25% of the bone surrounding the drill hole One or two cells per field of view within the drill hole Less than 25% of the field of view within the drill hole occupied by cavities lined with osteoblasts One or two osteoclasts per field of view within the drill hole Less than 25% of the drill hole occupied by fibrous tissue Less than 25% of the drill hole occupied by cartilage
2 Occupying up to 50% of the bone surrounding the drill hole Up to five cells per field of view within the drill hole Up to the 50 % of the field of view occupied by cavities lined with osteoblasts Up to five osteoclasts per field of view within the drill hole Up to 50% of the drill hole occupied by fibrous tissue Up to 50% of the drill hole occupied by cartilage
3 Occupying more than 50% of the bone surrounding the drill hole More than five cells per field of view within the drill hole More than 50% of the field of view occupied by cavities lined with osteoblasts More than five osteoclasts per field of view within the drill hole More than 50% of the drill hole occupied by fibrous tissue More than 50% of the drill hole occupied by cartilage
  1. The slides were examined with a light microscope (Leica DMR) at different magnifications (10×, 20× and 40×).