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Table 1 Correspondence of the score (0–3) for the histological findings for each parameter considered during semiquantitative histopathological evaluation.

From: Preliminary study on the effect of parenteral naloxone, alone and in association with calcium gluconate, on bone healing in an ovine "drill hole" model system

Grade

Surrounding Cavities

Macrophages Mesenchymal Cells

Osteoblasts

Osteoclasts

Fibrous Tissue

Cartilage

0

None

None

None

None

None

None

1

Occupying less than 25% of the bone surrounding the drill hole

One or two cells per field of view within the drill hole

Less than 25% of the field of view within the drill hole occupied by cavities lined with osteoblasts

One or two osteoclasts per field of view within the drill hole

Less than 25% of the drill hole occupied by fibrous tissue

Less than 25% of the drill hole occupied by cartilage

2

Occupying up to 50% of the bone surrounding the drill hole

Up to five cells per field of view within the drill hole

Up to the 50 % of the field of view occupied by cavities lined with osteoblasts

Up to five osteoclasts per field of view within the drill hole

Up to 50% of the drill hole occupied by fibrous tissue

Up to 50% of the drill hole occupied by cartilage

3

Occupying more than 50% of the bone surrounding the drill hole

More than five cells per field of view within the drill hole

More than 50% of the field of view occupied by cavities lined with osteoblasts

More than five osteoclasts per field of view within the drill hole

More than 50% of the drill hole occupied by fibrous tissue

More than 50% of the drill hole occupied by cartilage

  1. The slides were examined with a light microscope (Leica DMR) at different magnifications (10×, 20× and 40×).