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Table 3 Diagnostic performance of anti-CCP2 antibodies and RF in rheumatoid arthritis

From: Diagnostic value of anti-cyclic citrullinated peptide antibodies in Greek patients with rheumatoid arthritis

Anti-CCP2 R.A. vs non R.A. R.A. vs other diseases R.A. vs blood donors
AUC 0.90 (95% CI: 0.87 – 0.93) 0.87 (95% CI: 0.83 – 0.91) 0.95 (95% CI: 0.92 – 0.97)
Sensitivity* 63.6% (95% CI: 55.8% – 70.8%) 63.6% (95% CI: 55.8% – 70.8%) 63.6% (95% CI: 55.8% – 70.8%)
Specificity* 95.0% (95% CI: 91.7% – 97.0%) 92.1% (95% CI: 87.2% – 95.3%) 100% (95% CI: 96.4% – 100%)
PPV* 87.5% (95% CI: 80.1% – 92.4%) 87.5% (95% CI: 80.1% – 92.4%) 100% (95% CI: 96.2% – 100%)
NPV* 83.8% (95% CI: 80.0% – 87.0%) 74.55% (95% CI: 68.4% – 79.8%) 64.1% (95% CI: 56.3% – 71.2%)
LR +* 12.6 (95% CI: 10.9 – 14.7) 8.1 (95% CI: 6.95 – 9.41) Undefined
LR -* 0.38 (95% CI: 0.37 – 0.40) 0.39 (95% CI: 0.38 – 0.41) 0.36 (95% CI: 0.35 – 0.38)
Diagnostic OR* 33 (95% CI: 17.6 – 61.9) 20.5 (95% CI: 10.8 – 38.8) Undefined
RF R.A. vs non R.A. R.A. vs other diseases R.A. vs blood donors
AUC 0.71 (95% CI: 0.64 – 0.77) 0.719 (95% CI: 0.66 – 0.78) 0.682 (95% CI: 0.61 – 0.76)
Sensitivity* 59.09% (95% CI: 51.2% – 66.5%) 59.09% (95% CI: 51.2% – 66.5%) 59.09% (95% CI: 51.2% – 66.5%)
Specificity* 91.24% (95% CI: 87.3% – 94.0%) 87.93% (95% CI: 82.3% – 92.0%) 97.00% (95% CI: 91.6% – 99.0%)
PPV* 79.13% (95% CI: 70.8% – 85.6%) 81.25% (95% CI: 73.0% – 87.4%) 96.81% (95% CI: 91.0% – 98.9%)
NPV* 79.87% (95% CI: 75.1% – 83.9%) 70.83% (95% CI: 64.5% – 76.5%) 60.62% (95% CI: 52.9% – 67.9%)
LR +* 6.75 (95% CI: 6.13 – 7.43) 4.89 (95% CI: 4.39 – 5.46) 19.70 (95% CI: 10.10 – 38.43)
LR -* 0.45 (95% CI: 0.43 – 0.46) 0.47 (95% CI: 0.45 – 0.48) 0.42 (95% CI: 0.41 – 0.44)
Diagnostic OR* 15.05 (95% CI: 8.88 – 25.51) 10.52 (95% CI: 6.02 – 18.38) 46.70 (95% CI: 14.17 – 154.00)
  1. The AUC for anti-CCP2 antibodies of 0.90 (95% CI, 0.87–0.93) is higher than the AUC for RF of 0.71 (95% CI, 0.64–0.77), with no overlapping of the two CIs, and shows that the diagnostic value of anti-CCP2 antibodies is higher than RF in rheumatoid arthritis.
  2. AUC = area under the curve; PPV = positive predictive value; NPV = negative predictive value; LR+ = likelihood ratioof a positive test; LR- = likelihood ratioof a negative test OR = odds ratio