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Table 4 Association between baseline PINP, ICTP and change in femoral neck BMD

From: Bone turnover in elderly men: relationships to change in bone mineral density

  Symbol Estimate ± SE P-value
Analysis marker: sPINP    
   Estimated parameters    
Intercept (baseline) α 943 ± 13 <0.0001
Rate of change β -3.5 ± 1.0 0.0004
sPINP γ 0.7 ± 1.1 0.4953
   Variance components    
Baseline σ α 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGae8xSdegabaGaeGOmaidaaaaa@312F@ 16661 ± 2454 <0.001
Rate of change σ β 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGae8NSdigabaGaeGOmaidaaaaa@3131@ 44 ± 16 0.004
Covariance σ α β 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGae8xSdeMae8NSdigabaGaeGOmaidaaaaa@32CB@ 54 ± 131 0.692
Random error σ e 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGaemyzaugabaGaeGOmaidaaaaa@30E8@ 902 ± 130 <0.001
Analysis marker: sICTP    
   Estimated parameters    
Intercept (baseline) α 943 ± 13 <0.0001
Rate of change β -3.6 ± 1.0 0.0008
sICTP γ -0.6 ± 1.3 0.629
   Variance components    
Baseline σ α 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGae8xSdegabaGaeGOmaidaaaaa@312F@ 16643 ± 2453 <0.0001
Rate of change σ β 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGae8NSdigabaGaeGOmaidaaaaa@3131@ 43 ± 16 0.0041
Covariance σ α β 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGae8xSdeMae8NSdigabaGaeGOmaidaaaaa@32CB@ 56 ± 139 0.6848
Random error σ e 2 MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaaiiGacqWFdpWCdaqhaaWcbaGaemyzaugabaGaeGOmaidaaaaa@30E8@ 907 ± 131 <0.0001
  1. sICTP, serum C-terminal telopeptide of type I collagen; sPINP, serum N-terminal propeptide of type I collagen; BMD bone mineral density.
  2. Note of interpretation: Results in part (a) suggest that the BMD measurement (mg/cm2) for a subject at time t (denoted by BMD t ) can be represented by the equation: BMD t = 943 – 3.5*Year – 9.2* sPINP0, where "Year" is 0, 1, 2, ..., and sPINP0 is the measurement of sPINP at baseline for the subject. In other words, femoral neck BMD was decreased by -3.5 mg/cm2 per year. There was no significant association between baseline sPINP and change in BMD (p = 0.4953). The interpretation of variance components is similar to that in Table 3.