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Table 4 Summary of effectiveness

From: Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice

Strategy Efficacy Appropriate prescribing Adherence
Upper gastrointestinal injury
Coxib Extensive, robust evidence Low Effective
NSAID + PPI Surrogate only Low Low adherence
NSAID + H2A Surrogate only Low Low adherence
Lower gastrointestinal injury
Coxib Some evidence of efficacy Low Effective
NSAID + PPI Some evidence of lack of efficacy Low Low adherence
NSAID + H2A No evidence Low Low adherence
  1. Summarised from Hooper et al, 2004 [24].