Knee loading stimulates cortical bone formation in murine femurs

Table 1 Bone formation in periosteum and endosteum with knee loading

		MS/BS (%)	p value	MAR (μm/day)	p value	BFR/BS (μm³/μm²/year)	p value
5 Hz
Periosteum	control	11.62 ± 1.18	NS	0.20 ± 0.01	NS	8.51 ± 0.84	NS
	loading	14.04 ± 1.82		0.22 ± 0.01		11.50 ± 1.67
Endosteum	control	11.35 ± 1.80	NS	0.21 ± 0.01	NS	8.88 ± 1.53	NS
	loading	13.00 ± 2.42		0.22 ± 0.01		10.56 ± 1.98
10 Hz
Periosteum	control	10.60 ± 1.31	< 0.05	0.20 ± 0.01	< 0.01	7.96 ± 1.28	< 0.05
	loading	14.58 ± 1.27		0.26 ± 0.02		13.96 ± 1.75
Endosteum	control	10.22 ± 2.89	NS	0.20 ± 0.01	NS	7.63 ± 2.25	NS
	loading	11.89 ± 2.70		0.22 ± 0.01		9.37 ± 2.31
15 Hz
Periosteum	control	10.61 ± 1.44	< 0.05	0.20 ± 0.01	< 0.001	7.95 ± 1.28	< 0.01
	loading	18.09 ± 2.52		0.28 ± 0.01		18.69 ± 3.13
Endosteum	control	14.14 ± 2.15	NS	0.22 ± 0.01	NS	11.69 ± 2.03	NS
	loading	17.10 ± 2.10		0.24 ± 0.01		14.99 ± 2.23
20 Hz
Periosteum	control	11.81 ± 1.50	NS	0.20 ± 0.01	NS	9.04 ± 1.48	NS
	loading	13.48 ± 1.33		0.23 ± 0.01		11.06 ± 1.10
Endosteum	control	14.17 ± 2.50	NS	0.21 ± 0.01	NS	10.55 ± 1.79	NS
	loading	15.97 ± 2.07		0.22 ± 0.02		12.67 ± 1.65

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