Table 2 Human experimental groups

HColl/CFA (n = 8 for comparison to 4-week groups) (n = 4 for comparison to 12-week groups)

Positive control; human collagen with complete Freund's adjuvant, euthanized 3 weeks after injection

HColl/IFA (n = 8 for comparison to 4-week groups) (n = 4 for comparison to 12-week groups)

Positive control; human collagen with incomplete Freund's adjuvant, euthanized 3 weeks after injection

Hu-UP-4 (n = 8)

Unprocessed human graft, 4 weeks implantation

Hu-P-4 (n = 8)

Photooxidized human graft, 4 weeks implantation

Hu-S-4 (n = 4)

Negative control; sham operation, euthanized 4 weeks post-op

Hu-UP-12 (n = 8)

Unprocessed human graft, 12 weeks implantation

Hu-P-12 (n = 7)

Photooxidized human graft, 12 weeks implantation

Hu-S-12 (n = 8)

Negative control; sham operation, euthanized 12 weeks post-op